Progression of glucose intolerance and cardiometabolic risk factors in Chinese women with polycystic ovary syndrome
Refereed conference paper presented and published in conference proceedings


摘要Polycystic ovary syndrome is associated with increased metabolic risk, though data in the Chinese population is limited. Our group has established a registry of > 300 Chinese patients with PCOS, with detailed documentation of baseline characteristics and metabolic evaluation. In this study, we aim to conduct a comprehensive follow-up study in order to describe the progression of cardiometabolic risk factors in Chinese PCOS subjects, approximately 10 years after the baseline evaluation. To date, a total of 116 Chinese women with PCOS diagnosed by the Rotterdam criteria (mean age: 44.5 ±4.0 years; mean BMI: 27.0 ± 5.0 kg/m2) have completed the follow-up evaluation. At the time of their baseline evaluation (mean age: 34.4 ± 3.9 years; mean BMI: 26.2 ± 5.3 kg/m2), the frequency of impaired glucose regulation (IFG/IGT/DM), hypertension, and hyperlipidemia was: 42/116 (36.2%), 21/115 (18.3%), 66/116 (56.9%) respectively. Mean BMI at follow up evaluation increased from 26.2 ± 5.3 kg/m2 to 27.0 ± 5.0 kg/m2. The progression of impaired glucose regulation of PCOS subjects within these 10 years showed that 9/116 (7.8%) of PCOS subjects have progressed from NGT to DM, 1/116 (0.8%) progressed from NGT to IFG, 4/116 (3.4%) progressed from IGT to DM, and 8/116 (6.9%) progress from IFG to DM. We found that a total of 45/116 (38.8%) of PCOS subjects are having impaired glucose regulation 10 years after the baseline evaluation. Within these 10 years, 22/115 (19.1%) of the PCOS subjects progress from normal BP to hypertension. The total percentage of PCOS subjects who have hypertension in the follow up evaluation increased to 41/115 (35.7%). Furthermore, 14/113 (12.1%) of the PCOS subjects progress from normal lipid profile to dyslipidemia. It was found that after 10 years, total PCOS patients who are having dyslipidemia increased to 72/113 (63.7%). It was also demonstrated that there is a significant increase in weight, BMI, WH ratio, SBP, DBP, fasting glucose, 2-hr glucose and triglyceride of PCOS subjects between their baseline and follow-up study (0.001
著者Ng YH, Cheung LP, Li TC, Huang J, Liu KH, Ma RCW
會議名稱14th Annual Meeting, Androgen Excess and PCOS Society
會議地點Lorne, Australia

上次更新時間 2018-23-01 於 03:23