Progression of glucose intolerance and cardiometabolic risk factors in Chinese women with polycystic ovary syndrome
Refereed conference paper presented and published in conference proceedings


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AbstractPolycystic ovary syndrome is associated with increased metabolic risk, though data in the Chinese population is limited. Our group has established a registry of > 300 Chinese patients with PCOS, with detailed documentation of baseline characteristics and metabolic evaluation. In this study, we aim to conduct a comprehensive follow-up study in order to describe the progression of cardiometabolic risk factors in Chinese PCOS subjects, approximately 10 years after the baseline evaluation. To date, a total of 116 Chinese women with PCOS diagnosed by the Rotterdam criteria (mean age: 44.5 ±4.0 years; mean BMI: 27.0 ± 5.0 kg/m2) have completed the follow-up evaluation. At the time of their baseline evaluation (mean age: 34.4 ± 3.9 years; mean BMI: 26.2 ± 5.3 kg/m2), the frequency of impaired glucose regulation (IFG/IGT/DM), hypertension, and hyperlipidemia was: 42/116 (36.2%), 21/115 (18.3%), 66/116 (56.9%) respectively. Mean BMI at follow up evaluation increased from 26.2 ± 5.3 kg/m2 to 27.0 ± 5.0 kg/m2. The progression of impaired glucose regulation of PCOS subjects within these 10 years showed that 9/116 (7.8%) of PCOS subjects have progressed from NGT to DM, 1/116 (0.8%) progressed from NGT to IFG, 4/116 (3.4%) progressed from IGT to DM, and 8/116 (6.9%) progress from IFG to DM. We found that a total of 45/116 (38.8%) of PCOS subjects are having impaired glucose regulation 10 years after the baseline evaluation. Within these 10 years, 22/115 (19.1%) of the PCOS subjects progress from normal BP to hypertension. The total percentage of PCOS subjects who have hypertension in the follow up evaluation increased to 41/115 (35.7%). Furthermore, 14/113 (12.1%) of the PCOS subjects progress from normal lipid profile to dyslipidemia. It was found that after 10 years, total PCOS patients who are having dyslipidemia increased to 72/113 (63.7%). It was also demonstrated that there is a significant increase in weight, BMI, WH ratio, SBP, DBP, fasting glucose, 2-hr glucose and triglyceride of PCOS subjects between their baseline and follow-up study (0.001
All Author(s) ListNg YH, Cheung LP, Li TC, Huang J, Liu KH, Ma RCW
Name of Conference14th Annual Meeting, Androgen Excess and PCOS Society
Start Date of Conference10/11/2016
End Date of Conference12/11/2016
Place of ConferenceLorne, Australia
Country/Region of ConferenceAustralia
Year2016
Month11
LanguagesEnglish-United Kingdom

Last updated on 2018-23-01 at 03:23