The effect of adipose-derived stem cells from diabetic individuals on the characteristics of breast cancer cells
Refereed conference paper presented and published in conference proceedings


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AbstractBackground: Breast carcinoma is the most common invasive cancer in women, contributing to the highest percentage of cancer-related death. Previous studies have shown that diabetes and obesity are associated with breast cancer growth and progression. On the other hand, there is accumulating evidence that adipose-derived stem cells (ADSCs) may contribute to breast tumor microenvironment. Interestingly, ADSCs were shown to have different properties in normal and diabetic individuals. Here, we explored the possible role of ADSCs in breast cancer progression in diabetic condition.
Materials and methods: Breast cancer cells MCF-7 and MDA-MB-231 were co-cultured with ADSCs isolated from either Dock7m+/+Leprdb mice (control model) or +Leprdb/+Leprdb mice (diabetes and obesity disease model). Proliferation and migration properties were assessed by cell counting and MTT and transwell migration assay, respectively. Gene expression was determined by quantitative PCR.
Results: Our results showed that ADSCs from diabetic mice had a stronger effect in enhancing breast cancer cell proliferation and migration than ADSCs from control mice. Quantitative PCR revealed that ADSCs from diabetic and control mice had differential gene expressions. Further experiments will be conducted to examine if these genes contribute to the differential effects of ADSCs from different sources to breast cancer progression.
Conclusions: These findings would provide novel insights on the roles of ADSCs in breast tumor progression in diabetic individuals.
All Author(s) ListSuk Ying Tsang, Ka Long Yau
Name of ConferenceEACR-AACR-SIC Special Conference 2017
Start Date of Conference24/06/2017
End Date of Conference27/06/2017
Place of ConferenceFlorence
Country/Region of ConferenceItaly
Proceedings TitleEACR-AACR-SIC Special Conference 2017
Year2017
Month6
Pages61
LanguagesEnglish-United Kingdom

Last updated on 2018-08-06 at 11:21