Total cosine R-to-T for predicting ventricular arrhythmic and mortality outcomes: a systematic review and meta-analysis
Publication in refereed journal


摘要Background: The total cosine R-to-T (TCRT), an vectorcardiographic marker reflecting the spatial difference between the depolarization and repolarization wavefronts, has been used to predict ventricular tachycardia/fibrillation (VT/VF) and sudden cardiac death (SCD) in different clinical settings. However, its prognostic value has been controversial.

Objective: This systematic review and meta-analysis evaluated the significance of TRCT in predicting arrhythmic and/or mortality endpoints.

Methods: PubMed and Embase databases were searched through 31st December 2016.

Results: Of the 890 studies identified initially, 8 observational studies were included in our meta-analysis. A total of 9194 patients, age 59 ± 2 years, 76 ± 5% male, were followed up for 44 ± 8 months. A decrease in TCRT (mean cut-off: 0.15 ± 0.30) was a significant predictor of the arrhythmic or mortality outcomes (hazard ratio, HR: 1.36, 95% CI: 1.15 to 1.60, P < 0.0001). When different diseases were analyzed, the HRs were: myocardial infarction (2.61, 95% CI: 0.84 to 8.12; P > 0.05) and systolic heart failure (2.44, 95% CI: 1.41 to 4.22; P < 0.01).

Conclusion: TCRT is an independent predictor of arrhythmic and mortality events, especially for systolic heart failure, and can provide additional risk stratification beyond the use of clinical parameters and traditional electrocardiogram markers.
著者G. Tse, M. Gong, C. Chan, YS. Chan, B. Yan, G. Li, P. Whittaker, SH. Wong, KO. Lui, WKK Wu, WT. Wong, T. Liu
期次suppl. 3
出版社Oxford University Press (OUP): Policy B - Oxford Open Option B

上次更新時間 2021-13-09 於 00:21