Low testosterone and clinical outcomes in Chinese men with type 2 diabetes mellitus - Hong Kong Diabetes Registry
Publication in refereed journal


摘要Aims: To assess the implications of low testosterone on cardiovascular risk factors, metabolic syndrome (MES) and clinical outcomes in Chinese men with Type 2 Diabetes (T2D).
Methods: A prospective cohort study carried out in a university hospital involving a consecutive cohort of 1239 Chinese men with T2D and a median disease duration of 9 years followed up for 4.8 years. Clinical characteristics, frequency of MES, serum total testosterone and clinical events were analyzed. Multivariate logistic regression was performed to examine the independent association of low testosterone with MES after adjustment for confounding covariates. Cox proportional hazards regression analysis was used to derive hazard ratio for clinical outcomes.
Results: More men with low testosterone had cardiovascular-renal disease and MES than those with normal testosterone. The adjusted odds ratio (OR) of low testosterone for MES was 2.63 (95% Confidence Interval [CI] 1.56-4.61). After a median follow-up of 4.8 years, the hazard ratio (HR) of low testosterone was 2.22 (95% CI 1.23-4.01) for incident nonprostate cancer. In a multivariate Cox-regression model, the HRs were attenuated but remained significant with adjustment for MES and renal parameters.
Conclusions: Chinese men with low testosterone had high prevalence of cardiovascular disease and MES with high incidence non-prostate cancer.
著者Kitty Kit-Ting Cheung, Eric Siu-Him Lau, Wing-Yee So, Ronald Ching-Wan Ma, Risa Ozaki, Alice Pik-Shan Kong, Francis Chun-Chung Chow, Juliana Chung-Ngor Chan, Andrea On-Yan Luk
期刊名稱Diabetes Research and Clinical Practice
頁次97 - 105
關鍵詞Testosterone, Type 2 diabetes, Metabolic syndrome, Mortality, Cancer
Web of Science 學科類別Endocrinology & Metabolism;Endocrinology & Metabolism

上次更新時間 2021-19-01 於 01:17