Statins reduce the risk of liver decompensation and death in chronic viral hepatitis: a propensity score weighted landmark analysis
Publication in refereed journal

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其它資訊
摘要Background
Decompensated liver disease due to portal hypertension leads to significant morbidity and mortality. Statins can modulate intrahepatic vascular tone, but the clinical significance remains uncertain.

Aim
To determine the effects of statin use on the risk of liver decompensation and death among patients with chronic viral hepatitis.

Methods
We conducted a population wide cohort study using a hospital based database from the Hong Kong Hospital Authority. Adults with chronic viral hepatitis without prior liver decompensation were identified from 2000 to 2012 by International Classification of Diseases, Ninth Revision, Clinical Modification, diagnostic codes. Statin use was defined as a cumulative defined daily dose of >28. Landmark analysis was used to overcome immortal time bias. Propensity score weighting was further performed to minimise baseline confounders. Primary outcome was a composite of portal hypertension related liver decompensation events, with adjustment for death as a competing risk.

Results
A total of 69 184 patients with chronic viral hepatitis (2053 statin users and 67 131 statin non‐users) were identified for the 2‐year landmark analysis. After propensity score weighting of 23 baseline covariates, statin use was associated with a significant reduction in composite liver decompensation events (HR: 0.55; 95% CI: 0.36‐0.83; P = .005), ascites (HR: 0.57; 95% CI: 0.36‐0.92; P = .02), and a dose‐dependent decrease in death (HR: 0.87; 95% CI: 0.76‐0.99; P = .035) relative to no statin use.

Conclusions
Patients with chronic viral hepatitis who used statins have a reduced risk of liver decompensation and death compared to non‐users in this propensity score weighted landmark analysis.
著者Wong JCT, Chan HLY, Tse YK, Yip TCF, Wong VWS, Wong GLH
期刊名稱Alimentary Pharmacology and Therapeutics
出版年份2017
月份11
卷號46
期次10
出版社Wiley
頁次1001 - 1010
國際標準期刊號0269-2813
電子國際標準期刊號1365-2036
語言英式英語

上次更新時間 2020-21-11 於 02:27