Environmental and Genetic Determinants for Early-life Wheezing: Findings From a Birth Cohort in Hong Kong
Refereed conference paper presented and published in conference proceedings


摘要Introduction: Given the importance of early-life wheezing as a strong risk factor for subsequent asthma, the identification of early-life determinants for wheezing phenotypes can improve our prediction for the development of childhood asthma. Ten asthma loci were identified in the genome-wide association study by GABRIEL Consortium. Nonetheless, the relevance of these loci on early-life wheezing remains unclear. This birth cohort study characterized both environmental and genetic determinants for early-life wheezing.

Methods: Early-life factors, environmental factors and occurrence of wheezing phenotypes of 149 healthy Chinese neonates born in September 2012 were prospectively assessed at baseline and 9 and 24 months. Buccal swab samples were genotyped for single-nucleotide polymorphisms (SNPs) reported by GABRIEL using TaqMan genotyping assays. Linear regression and binary logistic regression were used to identify the genetic and environmental risk factors for wheezing.

Results: Adjusted for gender and family history of asthma/eczema as covariates, presence of household smokers (odds ratio [OR] 5.89, 95% confidence interval [CI] 1.02-33.84; P=0.047) and furry pet exposure (OR 6.47, 95% CI 1.21-34.69; P=0.029) at birth were risk factors for current wheeze at 9 months. These exposures were also associated with increased risk for wheeze ever both at 9 months (OR 3.99, 95% CI 1.35-11.84; P=0.012 and OR 3.51, 95% CI 1.06-11.59; P=0.040) and 24 months (OR 2.68, 95% CI 1.03-7.00; P=0.044 and OR 3.81, 95% CI 1.31-11.08; P=0.014). Besides, visible mould or dampness at home increased the risk for current wheeze at 9 months (OR 10.53, 95% CI 1.17-94.47; P=0.035). Concerning the genetic factors, rs2284033 in IL2RB was weakly associated with current wheeze at 9 months (OR 9.32, 95% CI 1.22-71.08; P=0.031), while rs11650680 in TOP2A was associated with wheeze ever at 9 months (OR 0.27, 95% CI 0.08-0.91; P=0.035) and rs1295686 in IL13 with wheeze ever at 24 months (OR 2.51, 95% CI 1.01-6.26; P=0.049). All other SNPs were not associated with any wheezing traits.

Conclusions: This study identifies exposures to passive smoking, pet keeping and domestic visible mould or dampness as risk factors for wheezing phenotypes at 9 and 24 months. IL2RB, TOP2A and IL13 appear to be candidate genes for early-life wheezing, which should be replicated in larger cohorts. (funded by Research Committee’s One-off Fund for Research [3132910] and Direct Grant for Research [4054292] of CUHK)
著者Agnes Sze-Yin Leung, Ting-Fan Leung, Man-Fung Tang, Wing-Hung Tam, Hing-Yee Sy, Gary Wing-Kin Wong
會議名稱The 13th Congress of Asian Society for Paediatric Research
會議地點Hong Kong
會議論文集題名The 13th Congress of Asian Society for Pediatric Research. Excellence in Child Health From Genes to Communities

上次更新時間 2018-29-11 於 16:25