Environmental and Genetic Determinants for Early-life Wheezing: Findings From a Birth Cohort in Hong Kong
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AbstractIntroduction: Given the importance of early-life wheezing as a strong risk factor for subsequent asthma, the identification of early-life determinants for wheezing phenotypes can improve our prediction for the development of childhood asthma. Ten asthma loci were identified in the genome-wide association study by GABRIEL Consortium. Nonetheless, the relevance of these loci on early-life wheezing remains unclear. This birth cohort study characterized both environmental and genetic determinants for early-life wheezing.

Methods: Early-life factors, environmental factors and occurrence of wheezing phenotypes of 149 healthy Chinese neonates born in September 2012 were prospectively assessed at baseline and 9 and 24 months. Buccal swab samples were genotyped for single-nucleotide polymorphisms (SNPs) reported by GABRIEL using TaqMan genotyping assays. Linear regression and binary logistic regression were used to identify the genetic and environmental risk factors for wheezing.

Results: Adjusted for gender and family history of asthma/eczema as covariates, presence of household smokers (odds ratio [OR] 5.89, 95% confidence interval [CI] 1.02-33.84; P=0.047) and furry pet exposure (OR 6.47, 95% CI 1.21-34.69; P=0.029) at birth were risk factors for current wheeze at 9 months. These exposures were also associated with increased risk for wheeze ever both at 9 months (OR 3.99, 95% CI 1.35-11.84; P=0.012 and OR 3.51, 95% CI 1.06-11.59; P=0.040) and 24 months (OR 2.68, 95% CI 1.03-7.00; P=0.044 and OR 3.81, 95% CI 1.31-11.08; P=0.014). Besides, visible mould or dampness at home increased the risk for current wheeze at 9 months (OR 10.53, 95% CI 1.17-94.47; P=0.035). Concerning the genetic factors, rs2284033 in IL2RB was weakly associated with current wheeze at 9 months (OR 9.32, 95% CI 1.22-71.08; P=0.031), while rs11650680 in TOP2A was associated with wheeze ever at 9 months (OR 0.27, 95% CI 0.08-0.91; P=0.035) and rs1295686 in IL13 with wheeze ever at 24 months (OR 2.51, 95% CI 1.01-6.26; P=0.049). All other SNPs were not associated with any wheezing traits.

Conclusions: This study identifies exposures to passive smoking, pet keeping and domestic visible mould or dampness as risk factors for wheezing phenotypes at 9 and 24 months. IL2RB, TOP2A and IL13 appear to be candidate genes for early-life wheezing, which should be replicated in larger cohorts. (funded by Research Committee’s One-off Fund for Research [3132910] and Direct Grant for Research [4054292] of CUHK)
All Author(s) ListAgnes Sze-Yin Leung, Ting-Fan Leung, Man-Fung Tang, Wing-Hung Tam, Hing-Yee Sy, Gary Wing-Kin Wong
Name of ConferenceThe 13th Congress of Asian Society for Paediatric Research
Start Date of Conference06/10/2017
End Date of Conference08/10/2017
Place of ConferenceHong Kong
Country/Region of ConferenceHong Kong
Proceedings TitleThe 13th Congress of Asian Society for Pediatric Research. Excellence in Child Health From Genes to Communities
Article number237
LanguagesEnglish-United Kingdom

Last updated on 2018-29-11 at 16:25