Short Sleep Duration Increases Metabolic Impact in Healthy Adults: A Population-Based Cohort Study
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The metabolic impact of inadequate sleep has not been determined in healthy individuals outside laboratories. This study aims to investigate the impact of sleep duration on five metabolic syndrome components in a healthy adult cohort.
A total of 162121 adults aged 20-80 years (men 47.4%) of the MJ Health Database, who were not obese and free from major diseases, were recruited and followed up from 1996 to 2014. Sleep duration and insomnia symptoms were assessed by a self-administered questionnaire. Incident cases of five metabolic syndrome components were identified by follow-up medical examinations. Cox proportional hazard ratios (HRs) were calculated for three sleep duration categories "< 6 hours/day (short)," "6-8 hours/day (regular)," and "> 8 hours/day (long)" with adjustment for potential confounding factors. Analyses were stratified by insomnia symptoms to assess whether insomnia symptoms modified the association between sleep duration and metabolic syndrome.
Compared to regular sleep duration, short sleep significantly (p < .001) increased the risk for central obesity by 12% (adjusted HR 1.12 [1.07-1.17]), for elevated fasting glucose by 6% (adjusted HR 1.06 [1.03-1.09]), for high blood pressure by 8% (adjusted HR 1.08 [1.04-1.13]), for low high-density lipoprotein-cholesterol by 7% (adjusted HR 1.07 [1.03-1.11]), for hypertriglyceridemia by 9% (adjusted HR 1.09 [1.05-1.13]), and for metabolic syndrome by 9% (adjusted HR 1.09 [1.05-1.13]). Long sleep decreased the risk of hypertriglyceridemia (adjusted HR 0.89 [0.84-0.94]) and metabolic syndrome (adjusted HR 0.93 [0.88-0.99]). Insomnia symptoms did not modify the effects of sleep duration.
Sleep duration may be a significant determinant of metabolic health.
Acceptance Date07/07/2017
All Author(s) ListHan-Bing Deng, Tony Tam, Benny Chung-Ying Zee, Roger Yat-Nork Chung, Xuefen Su, Lei Jin, Ta-Chien Chan, Ly-Yun Chang, Eng-Kiong Yeoh, Xiang Qian Lao
Journal nameSLEEP
Volume Number40
Issue Number10
PublisherOxford University Press (OUP): Policy B - Oxford Open Option D - CC-BY
Article numberzsx130
LanguagesEnglish-United Kingdom

Last updated on 2021-18-01 at 01:50