Therapeutic mechanisms of dopaminergic drug treatment on motor recovery in ischemic stroke
Other conference paper


摘要The development of effective treatment for ischemic stroke has been a major challenge especially for chronic patients, as available neuroprotective and thrombolytic agents do not promote functional recovery in these patients. Recent clinical studies have shown that administration of dopamine agonists or restoring central dopamine level via levodopa can substantially improve motor performance after stroke. However, the mechanisms of dopaminergic treatment on motor recovery are not fully understood. In this study, we tested the hypothesis that levodopa promotes functional recovery by enhancing cortical neuroplasticity. In a rodent model of focal ischemic stroke induced by photothrombosis, we assessed the integrity of cortical dopaminergic system and found that it is significantly disrupted by focal stroke. Through a 3-week daily treatment of levodopa, we recapitulated its beneficial effects on sensorimotor function by subjecting the animals to various motor tasks, including open-field test, rotarod performance test, limb-use asymmetry test and horizontal ladder test. Histological analysis of dendritic and spine morphology, as well as expression of synaptic proteins by immunostaining and Western blotting, support that peri-lesional tissue remodeling occurring after stroke is enhanced by levodopa. These findings are accompanied by facilitated synaptic plasticity measured in vivo. We conclude that modulation of dopaminergic transmission is a promising therapeutic strategy for stroke rehabilitation.
著者Ya KE, Leo Y.C. YAN, Yuehong LIU, Zhong-Ming QIAN
會議名稱The 39 Annual Meeting of the Japan Neuroscience Society

上次更新時間 2018-23-01 於 04:40