Co-Existing Sarcopenia And Osteoporotic Fracture Healing Of Senescence Accelerated Mouse Enhanced By Low-Magnitude High-Frequency Vibration
Refereed conference paper presented and published in conference proceedings


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AbstractObjective: Sarcopenia is a geriatric syndrome characterized by loss of muscle mass and function with a high prevalence in fragility fracture patients1. Our pervious data2 validated senescence-accelerated mouse prone 8 (SAMP8) as animal model of osteoporotic fracture with sarcopenia and senescence-accelerated mouse Resistant 1 (SAMR1) as control. In this study, we evaluated the efficacy of Low-magnitude High-frequency Vibration (LMHFV) on osteoporotic fracture healing in the presence of sarcopenia.
Method: Closed fracture was created at the right femur of 8-month-old SAMP8 and SAMR1. Then the mice were randomized to either control (SAMP8 n=25, SAMR1 n=25) with no treatment or LMHFV (SAMP8-V n=25, SAMR1-V n=25) with LMHFV treatment. Radiographs were taken weekly post-fracture. Micro CT and histology of the fractured femora were performed at week 2, 4, 6. Mechanical test of femora were performed at week 4 and 6.
Results: At week 2, callus size of SAMP8 was significantly smaller than SAMR1 while callus formation was enhanced in SAMP8-V than SAMP8. At week 4, SAMP8 showed significantly poorer mechanical properties than SAMR1 but enhanced in SAMP8-V. At week 6, callus size was larger in SAMP8 than SAMR1 and decreased in SAMP8-V group compared to SAMP8 group despite not significant.
Summary and Conclusions: Better callus formation at the reparative phase was showed by larger callus at week 2 of SAMR1 than SAMP8 while callus formation was enhanced in SAMP8-V by LMHFV. Smaller callus at week 6 also indicated a faster and better bone remodeling in SAMR1 than SAMP8 and LMHFV seemed to also enhance the this process. Better mechanical properties at week 4 showed a better healing status of the callus of SAMP8-V and groups than SAMP8 group. In conclusion, osteoporotic fracture healing was impaired in sarcopenic SAMP8 mice while LMHFV partly enhanced the osteoporotic fracture healing in the presence of sarcopenia.
Acceptance Date09/03/2017
All Author(s) ListNing Zhang, Kwok-Sui Leung, Simon Kwoon-Ho Chow, Wing-Hoi Cheung
Name of Conference44th European Calcified Tissue Society Congress
Start Date of Conference13/05/2017
End Date of Conference16/05/2017
Place of ConferenceSalzburg
Country/Region of ConferenceAustria
Year2017
LanguagesEnglish-United States
KeywordsLMHFV, sarcopenia, osteoporotic fracture healing

Last updated on 2018-14-05 at 09:43