Long-term mortality and major adverse cardiovascular events in patients with borderline ankle brachial index: a 15-year follow-up study
Refereed conference paper presented and published in conference proceedings

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Borderline ankle brachial index (ABI) has been associated with higher incidence of mobility loss and risk of peripheral arterial disease (PAD). This study aimed to evaluate long-term cardiovascular (CV) outcomes in patients with borderline ABI.

We retrospectively analyzed consecutive patients who underwent ABI assessment in our institution between January 2000 and December 2005. Clinical outcomes including mortality and major adverse CV events (MACE, including mortality, myocardial infarction, stroke and lower limb major amputation) up to 15 years (mean 11.8±2.3 years) were compared between 3 groups of patients according to baseline ABI: normal (1.00 to 1.40), borderline (0.91 to 0.99) and PAD (≤0.90). Multivariate Cox proportional hazards regression was used to evaluate long-term mortality risk of borderline ABI.

Of 689 patients (70.1±11.8 years, 58.6% men), 20.2% (n=139), 9.0% (n=62) and 70.8% (n=488) had normal, borderline ABI and PAD, respectively. Cumulative incidence of all-cause mortality was higher in patients with PAD (74.4%) and borderline ABI (71.0%) than in patients with normal ABI (54.7%, p<0.01). Adjusted mortality risks were significantly higher in patients with PAD (Hazard Ratio (HR) 1.60; 95%CI: 1.24-2.08; P<0.01) and borderline ABI (HR: 1.59; 95%CI: 1.09-2.31; P=0.02) compared to those with normal ABI. The risks of MACE were significantly higher in patients with PAD (HR: 1.90; 95%CI: 1.49-2.42; P<0.001) and borderline ABI (HR: 1.67; 95%CI: 1.18-2.37; P=0.004) than in those with normal ABI.

Patients with borderline ABI was associated with significantly higher risks of long-term mortality and MACE that are comparable to patients with PAD.
All Author(s) ListBryan P Yan, Christy KY Chan, April Ip, Nikki Lee, Toria Lee, James YW Lau
Name of ConferenceCongress of the European-Society-of-Cardiology (ESC)
Start Date of Conference27/08/2016
End Date of Conference31/08/2016
Place of ConferenceRome
Country/Region of ConferenceItaly
Proceedings TitleEuropean Heart Journal
Volume Number37
Issue NumberSupplement 1
Pages797 - 797
LanguagesEnglish-United States

Last updated on 2021-18-01 at 01:49