Effects of polycyclic aromatic compounds in fine particulate matter generated from household coal combustion on response to EGFR mutations in vitro
Publication in refereed journal

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其它資訊
摘要Induction of PM2.5-associated lung cancer in response to EGFR-tyrosine kinase inhibitors (EGFR-TKI) remains unclear. Polycyclic aromatic hydrocarbons (PAHs) and their polar derivatives (oxygenated PAHs: OPAHs and azaarenes: AZAs) were characterized in fine particulates (PM2.5) emitted from indoor coal combustion. Samples were collected in Xuanwei (Yunnan Province), a region in China with a high rate of lung cancer. Human lung adenocarcinoma cells A549 (with wild-type EGFR) and HCC827 (with EGFR mutation) were exposed to the PM2.5, followed by treatment with EGFR-TKI. Two samples showed significant and dose-dependent reduction in the cell viability in A549. EGFR-TKI further demonstrated significantly decreased in cell viability in A549 after exposure to the coal emissions. Chrysene and triphenylene, dibenzo[a,h]anthracene, benzo[ghi]perylene, azaarenes and oxygenated polycyclic aromatic hydrocarbons (carbonyl-OPAHs) were all associated with EGFR-TKI-dependent reduced cell viability after 72-h exposure to the PM2.5. The findings suggest the coal emissions could influence the response of EGER-TM in lung cancer cells in Xuanwei.
出版社接受日期30.08.2016
著者Kin-Fai Ho, Chih-Cheng Chang, Linwei Tian, Chi-Sing Chan, Benjamin A. Musa Bandowe, Ka-Hei Lui, Kang-Yun Lee, Kai-Jen Chuang, Chien-Ying Liu, Zhi Ning, Hsiao-Chi Chuang
期刊名稱Environmental Pollution
出版年份2016
月份11
卷號218
出版社ELSEVIER SCI LTD
頁次1262 - 1269
國際標準期刊號0269-7491
電子國際標準期刊號1873-6424
語言英式英語
關鍵詞Coal combustion, Lung cancer, Polycyclic aromatic compounds, Xuanwei
Web of Science 學科類別Environmental Sciences;Environmental Sciences & Ecology

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