Chemical components of respirable particulate matter associated with emergency hospital admissions for type 2 diabetes mellitus in Hong Kong
Publication in refereed journal

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其它資訊
摘要Background: Epidemiological studies have shown that short-termexposure to particulate matter (PM) mass is associated with diabetes morbidity and mortality, although inconsistencies still exist. Variation of chemical components in PM may have contributed to these inconsistencies. We hypothesize that certain components of respirable particulate matter (PM10), not simply PM10 mass, can exacerbate symptoms or cause acute complications for type 2 diabetes mellitus (T2DM).
Methods: We used a Poisson time-series model to examine the association between 17 chemical components of PM10 and daily emergency hospital admissions for T2DM among residents aged 65 years or above from January 1998 to December 2007 in Hong Kong. We estimated excess risk (ER%) for T2DM hospitalizations per interquartile range (IQR) increment in chemical component concentrations of days at lag(0) through lag(3), and the moving average of the same-day and previous-day (lag(0-1)) in single-pollutant models. To further evaluate the independent effects of chemical components on T2DM, we controlled for PM10 mass, major PM10 chemical components, and gaseous pollutants in two-pollutant models.
Results: In the single-pollutant models, PM10 components associated with T2DM admissions include: elemental carbon, organic carbon, nitrate, and nickel. The ER% estimates per IQR increment at lag(0-1) for these four components were 3.79% (1.63, 5.95), 3.74% (0.83, 6.64), 4.58% (2.17, 6.99), and 1.91% (0.43, 3.38), respectively. Risk estimates for nitrate and elemental carbon were robust to adjustment for co-pollutant concentrations.
Conclusions: Short-term exposure to some PM10 chemical components such as nitrate and elemental carbon increases the risk of acute complications or exacerbation of symptoms for the T2DM patients. These findings may have potential biological and policy implications.
出版社接受日期21.10.2016
著者Shengzhi Sun, Hong Qiu, Kin-Fai Ho, Linwei Tian
期刊名稱Environment International
出版年份2016
月份12
卷號97
頁次93 - 99
國際標準期刊號0160-4120
語言英式英語
關鍵詞Particulate matter, Chemical component, Air pollution, Diabetes, Time-series analysis
Web of Science 學科類別Environmental Sciences;Environmental Sciences & Ecology

上次更新時間 2021-16-09 於 23:59