Encapsulating pH-Responsive Doxorubicin-Phthalocyanine Conjugates in Mesoporous Silica Nanoparticles for Combined Photodynamic Therapy and Controlled Chemotherapy
Publication in refereed journal

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摘要Doxorubicin (Dox) was conjugated to a zinc(II) phthalocyanine (ZnPc) through an acid-cleavable hydrazone linker. This azido-containing conjugate was then anchored to the nanochannels of an alkyne-modified mesoporous silica nanoparticle (MSN) system via copper(I)-catalyzed azide–alkyne cycloaddition. An analogous nanosystem was also prepared by immobilization of a hydrazine-substituted ZnPc to the MSN followed by coupling with Dox. The release of Dox under acidic conditions was studied in phosphate-buffered saline. After internalization into human hepatocellular carcinoma HepG2 cells, these nanoparticles showed fluorescence not only for ZnPc, but also for Dox, suggesting that release of Dox was triggered by the acidic intracellular environment. The chemocytotoxic Dox together with singlet oxygen generated upon irradiation on the encapsulated ZnPc in these MSNs could kill the cells effectively. A synergistic cytotoxicity was suggested by a less-than-unity combination index. These nanoparticles function as both nanophotosensitizers for photodynamic therapy and as nanoplatforms for pH-controlled drug release.
出版社接受日期03.08.2017
著者Roy C. H. Wong, Dennis K. P. Ng, Wing-Ping Fong, Pui-Chi Lo
期刊名稱Chemistry - A European Journal
出版年份2017
月份11
日期21
卷號23
期次65
頁次16505 - 16515
國際標準期刊號0947-6539
電子國際標準期刊號1521-3765
語言美式英語
關鍵詞chemotherapy, doxorubicin; mesoporous silica nanoparticles, photodynamic therapy, phthalocyanines

上次更新時間 2020-18-10 於 02:35