A cell-selective glutathione-responsive tris(phthalocyanine) as a smart photosensitiser for targeted photodynamic therapy
Publication in refereed journal

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其它資訊
摘要A biotin-conjugated disulfide-linked tris(phthalocyanine) has been synthesised and characterised. As shown by electronic absorption and steady-state fluorescence spectroscopy methods, the compound remains non-aggregated in N,N-dimethylformamide, but is significantly aggregated in phosphate buffered saline with 1% Cremophor EL. The reduction in fluorescence intensity and singlet oxygen generation efficiency as compared with the monomeric counterpart suggests that the tris(phthalocyanine) exhibits an excellent self-quenching effect, particularly in an aqueous medium. Upon interaction with glutathione, both the fluorescence emission and singlet oxygen production can be restored as a result of the cleavage of the disulfide linkages, thereby releasing the phthalocyanine units and reducing their aggregation and self-quenching effects. With a biotin moiety, this tris(phthalocyanine) is preferentially taken up by the biotin-receptor-positive HeLa cells and activated by the intracellular glutathione, resulting in fluorescence recovery and photocytotoxicity with an IC50 value of 0.68 μM. This compound can therefore act as a dual functional photosensitiser.
出版社接受日期24.07.2017
著者Sun Y. S. Chow, Shirui Zhao, Pui-Chi Lo, Dennis K. P. Ng
期刊名稱Dalton Transactions
出版年份2017
月份9
日期14
卷號46
期次34
頁次11223 - 11229
國際標準期刊號1477-9226
電子國際標準期刊號1477-9234
語言美式英語

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