pH-Responsive Dimeric Zinc(II) Phthalocyanine in Mesoporous Silica Nanoparticles as an Activatable Nanophotosensitizing System for Photodynamic Therapy
Publication in refereed journal

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摘要An acid-cleavable acetal-linked zinc(II) phthalocyanine dimer with an azido terminal group (cPc) was prepared and conjugated to alkyne-modified mesoporous silica nanoparticles via copper(I)-catalyzed alkyne–azide cycloaddition reaction. For comparison, an amine-linked analogue (nPc) was also prepared as a non-acid-cleavable counterpart. These dimeric phthalocyanines were significantly self-quenched due to the close proximity of the phthalocyanine units inside the mesopores, resulting in much weaker fluorescence emission and singlet oxygen generation, both in N,N-dimethylformamide and in phosphate-buffered saline (PBS), compared with the free molecular counterparts. Under acidic conditions in PBS, the cPc-encapsulated nanosystem was activated in terms of fluorescence emission and singlet oxygen production. After internalization into human colon adenocarcinoma HT29 cells, it exhibited much higher intracellular fluorescence and photocytotoxicity compared to the nanosystem entrapped with nPc. The activation of this nanosystem was also demonstrated in tumor-bearing nude mice. The intratumoral fluorescence intensity increased gradually over 24 h, while for the nPc counterpart the fluorescence remained very weak. The results suggest that this nanosystem serves as a promising activatable nanophotosensitizing agent for photodynamic therapy.
出版社接受日期29.06.2017
著者Roy C. H. Wong, Sun Y. S. Chow, Shirui Zhao, Wing-Ping Fong, Dennis K. P. Ng , Pui-Chi Lo
期刊名稱ACS Applied Materials and Interfaces
出版年份2017
月份7
日期19
卷號9
期次28
頁次23487 - 23496
國際標準期刊號1944-8244
電子國際標準期刊號1944-8252
語言美式英語
關鍵詞activatable, mesoporous silica nanoparticle, photodynamic therapy, photosensitizer, phthalocyanine, self-quenching

上次更新時間 2020-18-10 於 02:35