White paper on guidelines concerning enteric nervous system stem cell therapy for enteric neuropathies
Publication in refereed journal

香港中文大學研究人員
替代計量分析
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其它資訊
摘要Over the last 20 years, there has been increasing focus on the development of novel stem cell based therapies for the treatment of disorders and diseases affecting the enteric nervous system (ENS) of the gastrointestinal tract (so-called enteric neuropathies). Here, the idea is that ENS progenitor/stem cells could be transplanted into the gut wall to replace the damaged or absent neurons and glia of the ENS. This White Paper sets out experts’ views on the commonly used methods and approaches to identify, isolate, purify, expand and optimize ENS stem cells, transplant them into the bowel, and assess transplant success, including restoration of gut function. We also highlight obstacles that must be overcome in order to progress from successful preclinical studies in animal models to ENS stem cell therapies in the clinic.
出版社接受日期02.04.2016
著者Alan J. Burns, Allan M. Goldstein, Donald F. Newgreen, Lincon Stamp, Karl-Herbert Schäfer, Marco Metzger, Ryo Hotta, Heather M. Young, Peter W. Andrews, Nikhil Thapar, Jaime Belkind-Gerson, Nadege Bondurand, Joel C. Bornstein, Wood Yee Chan, Kathryn Cheah, Michael D. Gershon, Robert O. Heuckeroth, Robert M.W. Hofstra, Lothar Just, Raj P. Kapur, Sebastian K. King, Conor J. McCann, Nandor Nagy, Elly Ngan, Florian Obermayr, Vassilis Pachnis, Pankaj J. Pasricha, Mai Har Sham, Paul Tam, Pieter Vanden Berghe
期刊名稱Developmental Biology
出版年份2016
月份9
日期15
卷號417
期次2
頁次229 - 251
國際標準期刊號0012-1606
語言英式英語
關鍵詞Enteric nervous system, Enteric neuropathies, Stem cells, Cell replacement therapy, Hirschsprung disease

上次更新時間 2021-26-01 於 02:21