Identification of Small Molecule Modulators of MicroRNA by Library Screening
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AbstractMicroRNAs (miRNAs) function as oncogenes or tumor suppressors and are dysregulated in cancer. miRNAs therefore represent promising therapeutic targets for cancer. Small molecules that could modulate the expression of miRNAs would thus have potential as anticancer agents. Library screening of small molecules targeting miRNAs is a useful technology platform for anticancer drug development. Here, we describe a hepatocellular carcinoma (HCC) cell-based luciferase reporter system which could be used to screen for small molecule modulators of tumor suppressor microRNA-34a.
All Author(s) ListXIAO Zhangang, CHEN Yangchao
All Editor(s) ListMarco F. Schmidt
Journal nameMethods in molecular biology (Clifton, N.J.)
Book titleDrug Target miRNA: Methods and Protocols
Series TitleMethods in Molecular Biology
Volume Number1517
PublisherHumana Press
Place of PublicationNew York
Pages169 - 178
LanguagesEnglish-United Kingdom
KeywordsmicroRNA, Cancer, Library screening, Small molecule

Last updated on 2021-19-11 at 00:15