Evaluation of Drug-Disease Interactions and Their Association with Unplanned Hospital Readmission Utilizing STOPP Version 2 Criteria
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AbstractBackground: Early hospital readmission is a common problem among geriatric patients and it is an indicator of poor patient health outcomes. Due to age-related physiological changes, polypharmacy, and multiple comorbidities, geriatric patients are more susceptible to adverse drug events, which are associated with increased hospital admission, mortality and healthcare costs. Limited staffing and resources create difficulties in the implementation of comprehensive STOPP version 2 criteria assessment into clinical practice.

Objective: The objective of the study is to examine the association between exposure to potentially inappropriate medications under selected STOPP version 2 criteria related to drug-disease interactions and unplanned early hospitalization within 28-days of index admission in elderly patients prescribed a potentially inappropriate medication.

Setting: A large single center public hospital in Hong Kong.
Methods: This retrospective single-center study reviewed patients greater than or equal to 75 years of age that were discharged with 5 or more medications including at least one selected medication listed in the STOPP version 2 criteria relating to drug-disease interactions.

Main Outcome Measure: Evaluation of the prevalence of potentially inappropriate medications caused solely by drug-disease interactions.
Results: A total of 182 patients with a mean age of 83.5 years were included in the study with anticholinergics being the most common PIM (22.4%). Potentially inappropriate medications (57.1% vs 17.1%, p < 0.001), gout (31% vs 11.5%, p = 0.003), and gastrointestinal disease (11.9% vs 2.5%, p = 0.026) were shown to increase risk of 28-day readmission, whereas all other factors assessed did not correlate with readmission.

Conclusion: A rapid evaluation of elderly patient discharge medications and concomitant disease states by a healthcare professional with the aid of the STOPP version 2 criteria could potentially reduce hospital readmissions or emergency department visits.
Acceptance Date02/05/2017
All Author(s) ListLau Hau Man, Justin Wade Tenney
Name of Conference77th FIP World Congress of Pharmacy and Pharmaceutical Sciences 2017
Start Date of Conference10/09/2017
End Date of Conference14/09/2017
Place of ConferenceSeoul, Korea
Country/Region of ConferenceSouth Korea
LanguagesEnglish-United States

Last updated on 2018-26-04 at 14:21