乳腺癌幹細胞近年的主要研究進展 (Some recent progress on breast cancer stem cells)
Publication in refereed journal

香港中文大學研究人員
替代計量分析
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其它資訊
摘要背景:隨著對乳腺癌發生、發展機制的不斷深入研究,乳腺癌幹細胞日益受到重視。
目的:對乳腺癌幹細胞的特徵、調控乳腺癌幹細胞的相關信號通路以及乳腺癌幹細胞與上皮間質轉化、乳腺癌轉移、腫瘤微環境、治療抵抗等方面的主要研究進展做一綜述。
方法:由第一作者以“Breast cancer,Stem cells,Signaling pathway,Epithelial mesenchymal transition,Tumor microenvironment”為關鍵詞,檢索PubMed等數據庫從2001至2017年的相關文獻,排除與文章研究目的無關及重複性的文章,納入符合標準的60篇文獻進行綜述。
結果與結論:腫瘤幹細胞學說的提出解釋了腫瘤轉移和復發的根本原因,為腫瘤治療提供一個新的研究思路,隨著對乳腺癌幹細胞的致病分子機制、特性和相關分子調控機制的深入研究,明確了乳腺癌幹細胞在乳腺癌發生、發展中所扮演的角色,對靶向乳腺癌幹細胞的腫瘤治療方法的研究具有重要指導意義。
BACKGROUND: With the in-depth exploration of the mechanism of breast cancer occurrence and increasing attention has been paid to breast cancer stem cell development.
OBJECTIVE: To review the main progress in the characteristics, related signaling pathways, epithelial- mesenchymal transition, breast cancer metastasis and tumor microenvironment about breast cancer stem cells.
METHODS: A computer-based retrieval of PubMed database was performed in order to search relevant articles published from 2001 to 2017, using the keywords of “breast cancer, stem cells, signaling pathway, epithelial- mesenchymal transition, tumor microenvironment”. After removal of repetitive or irrelevant articles, 60 articles were finally reviewed.
RESULTS AND CONCLUSION: The tumor stem cell theory explains the root cause of tumor metastasis and recurrence, and provides a new insight into the tumor treatment. With the further study on the molecular pathogenesis, characteristics and related molecular regulation mechanisms of breast cancer stem cells, the role of breast cancer stem cells is explicated in the development and progression of breast cancer, which is of great significance in the tumor treatment targeting breast cancer stem cells.
著者羅智萍 (Luo Zhi-ping), 劉碧珊 (Lau Clara Bik-san), 譚寧華 (Tan Ning-hua)
期刊名稱Zhongguo Zuzhi Gongcheng Yanjiu ==
出版年份2017
月份7
日期28
卷號21
期次21
出版社Zhongguo Zuzhi Gongcheng Yanjin Zazhishe
頁次3414 - 3419
國際標準期刊號2095-4344
語言簡體中文

上次更新時間 2020-25-10 於 02:12