Long-term persistence of immunity after hepatitis B vaccination: Is this substantiated by the literature?
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AbstractHepatitis B vaccination is held to provide life-long protection against hepatitis B virus (HBV) infection, but
evidence for this notion remains wanting, since no studies have assessed the vaccinees in their fourth decade of
life. Indeed, there are several reports indicating that despite vaccination in infancy, the prevalence of HBV
infection still increased with age in the vaccinees, and that both anti-HBs titer and anamnestic response declined
with age. Clearly it is time to clarify the long-term protection conferred by vaccination in infancy, and to
implement remedialmeasures such as booster doses of vaccine in subjects without immunoprotection.
Acceptance Date24/11/2016
All Author(s) ListTerence T. Lao
Journal nameHuman Vaccines and Immunotherapeutics
Year2017
Month4
Volume Number13
Issue Number4
PublisherTaylor & Francis Inc
Place of PublicationUSA
Pages918 - 920
ISSN2164-5515
eISSN2164-554X
LanguagesEnglish-United States
Keywordsage, anamnestic response, hepatitis B virus, immune persistence, vaccination in infancy

Last updated on 2020-15-10 at 02:49