Crosslinking for microbial keratitis
Publication in refereed journal

替代計量分析
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其它資訊
摘要Purpose of review: Microbial keratitis is one of the leading causes of ocular morbidity. The standard treatment consists of antibiotics, which is intensive and is fraught with risks of antibiotic resistance. Corneal collagen cross-linking (CXL) has recently been advocated as an adjunctive therapy for management of microbial keratitis. The addition of CXL to ongoing antimicrobial treatment can have a potential effect on overall duration of the disease, need for corneal transplantation, final visual outcome, and long-term impact on drug resistance pattern.
Recent findings: CXL has been used in cases with bacterial, fungal as well as amoebic keratitis. However, so far the reported results have been variable and the evidence is largely anecdotal. The debate over the safety and efficacy of this modality continues especially with regards to its utilization in early phases of the disease when the corneal involvement is limited to the anterior stroma.
Summary: CXL appears to be a promising adjunctive treatment in selective cases of mild to moderate bacterial keratitis. Its efficacy in fungal and amoebic keratitis is questionable. Treatment protocols in microbial keratitis need to be individualized. Long-term, prospective, randomized trials are needed to determine its usefulness in microbial keratitis.
著者Chan TC, Agarwal T, Vajpayee RB, Jhanji V
期刊名稱Current Opinion in Ophthalmology
出版年份2016
月份7
卷號27
期次4
頁次348 - 352
國際標準期刊號1040-8738
電子國際標準期刊號1531-7021
語言英式英語

上次更新時間 2021-03-03 於 02:11