Accuracy of Faecal Immunochemical Test to Predict Endoscopic and Histological Healing in Ulcerative Colitis: A Prospective Study Based on Validated Histological Scores
Publication in refereed journal

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其它資訊
摘要Background and Aims:

Endoscopic and histological healing are associated with improved clinical outcomes in ulcerative colitis [UC]. We aimed to investigate the predictive value of faecal immunochemical test [FIT] for endoscopic and histological healing in UC.

Methods:

We measured quantitative FIT and faecal calprotectin [FC] in 140 consecutive UC patients who underwent colonoscopy. We assessed the diagnostic accuracy of FIT for predicting endoscopic healing using the Mayo endoscopic subscore [MES 0/1] and for histological healing using the Geboes score [< 2.0] and Nancy index [grade ≤ 1]. The predictive abilities of FIT were compared with those of FC.

Results:

FIT had an area under the curve [AUC] of 0.77 (95% confidence interval [CI] 0.67–0.86, p < 0.001) for endoscopic healing, an AUC of 0.77 [95% CI 0.67–0.86, p < 0.001] using the Geboes score, and 0.77 [95% CI 0.66–0.85, p < 0.001] using the Nancy Index for histological healing. The AUC of FIT was comparable to that of FC for endoscopic healing [p = 0.773] and histological healing [p = 0.767–0.960], and was comparable to colonoscopy for histological healing [p = 0.384–0.673]. FIT < 50 ng/ml predicted endoscopic healing with a sensitivity, specificity, and positive predictive value [PPV] of 72%, 68%, and 82%, respectively, and for histological healing with a sensitivity, specificity, and PPV of 73–75%, 67%, and 78–80%, respectively. Combining FIT with FC led to a higher specificity [90%] for histological healing. Over 85% of patients with FIT < 50 ng/ml and FC < 50 μg/g achieved histological healing.

Conclusions:

FIT is highly sensitive and accurate to predict endoscopic and histological healing in UC. It represents a promising non-invasive tool for monitoring mucosal healing in UC.
出版社接受日期12.07.2017
著者Hai Yun Shi, Francis K. L. Chan, Anthony W. H. Chan, Akira Higashimori, Moe Kyaw, Jessica Y. L. Ching, Arthur K. C. Luk, Sunny H. Wong, Justin C. Y. Wu, Joseph J. Y. Sung, Siew C. Ng
期刊名稱Journal of Crohn's and Colitis
出版年份2017
月份9
卷號11
期次9
出版社Oxford University Press
頁次1071 - 1077
國際標準期刊號1873-9946
電子國際標準期刊號1876-4479
語言英式英語
關鍵詞Ulcerative colitis, mucosal healing, faecal immunochemical test

上次更新時間 2020-16-10 於 03:33