Can We Use ALBI Grade to Predict Post-Hepatectomy Mortality for Hepatocellular Carcinoma
Refereed conference paper presented and published in conference proceedings


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AbstractIntroduction: ALBI grade, a simple formula using albumin and bilirubin to reflect liver dysfunction of patients, was shown to have prognostic significance in long-term survival as well as post-hepatectomy liver failure for hepatocellular
carcinoma after curative treatment. The aim of this study was to evaluate the relationship between ALBI grade
and post-hepatectomy mortality after curative resection.

Methods: We performed a retrospective study using a prospectively collected surgical outcome monitoring database
from July 2009 to June 2015 to evaluate the use of ALBI grade in predicting various post-hepatectomy outcome for hepatocellular carcinoma. The primary outcome was 90-day mortality. Liver failure, massive blood loss, post-operative
sepsis and surgical site infection were used as secondary outcome. Other potential predictive factors of post-hepatectomy outcome were also analysed with univariate and multivariate analysis.
Results: 179 patients were recruited into this study, with 121 patients classified as ALBI grade 1 and 58 patients classified as ALBI grade 2 and 3. There was no significant difference in ASA class, type of hepatectomy, operation
time, rates of massive blood loss, post-operative sepsis and surgical site infection between the two groups. There was
no post-hepatectomy liver failure. Two patients (1.1Ψ) developed 90-day mortality, all in ALBI 1 group, with no
significant difference between groups. Type of hepatectomy, platelet count and bilirubin level were independent prognostic factors of post-op sepsis. ASA class was independent factor for massive blood loss and surgical site infection.

Conclusions: We observed no association between ALBI grade and early post-operative outcome after hepatectomy for HCC in our series. The result might be limited by the small sample size in a well selected group of HCC patients with low 90-day mortality rate. Further evaluation with larger sample is needed before we can understand how to apply ALBI grade in addition to the current standard of pre-hepatectomy assessment.
All Author(s) ListYue Sun Cheung, Paul Bo San Lai, Philip Ching Tak Ip, Charing Ching Ning Chong
Name of ConferenceThe 8th Asia-Pacific Primary Liver Cancer Expert Meeting (APPLE 2017)
Start Date of Conference14/07/2017
End Date of Conference16/07/2017
Place of ConferenceSingapore
Country/Region of ConferenceSingapore
Year2017
LanguagesEnglish-United Kingdom

Last updated on 2018-05-06 at 14:43