Pathological and Aging-Related Changes in EEG Alpha Activities During Eyes-Open Rest and Memory Retention
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其它資訊
摘要Objective:
Previous studies have reported pathological changes in EEG oscillations during eyes-closed rest, such as suppression in alpha power in elderly with mild cognitive impairment (MCI; Kwak, 2006; Cantero et al., 2009). Compared to eyes-closed rest, specific memory tasks involving pictures also evoked a decrease in alpha power during eyes-closed memory retention, with the decrease being weakened in MCI subjects (van der Hiele et al., 2007). Given the substantial EEG differences between eyes-open and eyes-closed rest (Barry et al., 2007), to evaluate the generality of such findings and their utility in MCI assessment, we examined EEG alpha activities during eyes-open rest and memory retention in a modified Sternberg task (figure 1; Sternberg, 1966; Jenson et al., 2002).

Methods:
Participants were 12 MCI subjects (M = 73.5 ± 4.5; 11 F), 14 elderly controls (EC; M = 72.6 ± 4.6; 6 F), and 15 young controls (YC; M = 20.9 ± 2.0; 9 F). A mixed ANOVA was run for band power (computed using a 4-Hertz window centering about the individual alpha frequency), with GROUP as a between-subject factor, and TASK (memory retention / rest) and ELECTRODE (Fz / Cz / Pz / Oz) as within-subject factors.

Results:
Distinct power spectra were observed across the two tasks (figure 2). The interaction among GROUP and TASK was significant (P < .001). Post-hoc tests revealed a pathological reduction in alpha power during rest in MCI subjects, as well as an aging-related reduction in alpha power during memory retention in both elderly groups (figure 3). Within-group t-tests revealed that the alpha power was significantly suppressed only for EC (P < .01) but not for MCI (P = .284); YC showed an opposite trend (P = .07).

Conclusion:
The differential group effects observed during eyes-open rest and memory retention
suggest that the two tasks provide qualitatively different information for discriminating the three groups. In particular, a reduction of alpha power during eyes-open rest state and a weakened alpha suppression during memory retention may serve well as biomarkers for mild cognitive impairment.
著者Manson Cheuk-Man Fong, Ivan Yifan Zou, Adrian Wong, Pauline W. L. Kwan, Vincent C. T. Mok, James William Minett, William Shi-Yuan Wang
會議名稱2016 International Psychogeriatric Association Asian Regional Meeting
會議開始日09.12.2016
會議完結日11.12.2016
會議地點Taipei
會議國家/地區台灣
出版年份2016
語言英式英語

上次更新時間 2018-20-01 於 18:01