Regular participation in prestroke leisure activities reduced risks of dementia and improved cognitive functions after stroke or transient ischemic attack: Results from the STRIDE study
Refereed conference paper presented and published in conference proceedings

替代計量分析
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其它資訊
摘要Background
To examine the effects of recent past leisure activities participation upon cognitive functions and risk of incident dementia after stroke.

Methods
In the Stroke Registry Investigating Cognitive Decline (STRIDE) study, 88 of 1,013 patients with stroke or transient ischemic attack (TIA) having no prestroke dementia were diagnosed to have incident poststroke dementia (PSD) 3-6 months after the index event. Regular participation was defined as participation of ≥30 minutes within 24 hours for ≥3 times a week in intellectual, recreational, social and physical activities over the year before the index event.

Results
Logistic regression analyses showed that regular participation in intellectual (RR 0.36, 95%CI 0.20-0.63) and stretching & toning physical exercise (0.37, 0.21-0.64) was significantly associated with a reduced risk of PSD after controlling for age, education, prestroke cognitive decline, stroke subtype, prior strokes and chronic brain changes including white matter changes, old infarcts and global atrophy. Results were similar in patients with past strokes in unadjusted models. Participation in increased number of activities in general (r=0.41, p<0.01) and in intellectual (r=0.40, p<0.01), recreational (r=0.24, p<0.01), strenuous aerobic (r=0.23, p<0.01) and mind-body (r=0.10, p<0.01) activities was associated with higher Mini-mental State Examination scores poststroke in models adjusted for prestroke cognitive decline.

Conclusions
Regular participation in intellectual activities and stretching & toning exercise was associated with a significantly reduced short-term risk of PSD in stroke or TIA patients with and without prior strokes. Participation in greater number of recent past leisure activities was associated with better poststroke cognitive performance.
著者Wong A, Lau AYL, Lo E, Tang M, Wang Z, Liu W, Tanner N, Chau N, Law L, Shi L, Chu WCW, Yang J, Xiong Y, Lam BYK, Au L, Soo Y, Leung TWH, Wong LKS, Lam LCW, Mok VCT
會議名稱Alzheimer’s Association International Conference 2016
會議開始日22.07.2016
會議完結日28.07.2016
會議地點Toronto
會議國家/地區加拿大
期刊名稱Alzheimer's & Dementia, Supplement
會議論文集題名Alzheimer's & Dementia
出版年份2016
月份7
卷號12
期次7 Supplement
出版社Elsevier B.V.
頁次P365 - P365
語言英式英語

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