The Impact of Air Pollution on Atherogenesis in Children in Hong Kong
Other conference paper


摘要BACKGROUND: Air pollution (AP) is an imminent global health hazard of the 21st century, in mainland China in particular. AP has been associated with prevalence of cardiovascular diseases, stroke and respiratory disorders.

AIM: To establish a clinical model of AP-related atherogenesis as a potential surrogate marker for atherosclerosis (coronary artery disease and stroke) prevention.

SUBJECTS AND METHODS: 976 school students (aged 8-14 years, boys 45.7%) with various AP (PM10, NO2, CO, O3 and SO2) exposure in urban and rural areas in Hong Kong were studied. PM10 concentrations were computed from atmospheric-chemical model of the Environmental Protection Department. Their school and home PM10 exposures were categorized in tertile of yearly AP. Carotid intima-media thickness (IMT) as atherosclerosis surrogate predictive of cardiovascular and stroke outcomes, were measured by high resolution B-mode ultrasound, using an automatic edge-detection software package (CV=0.995). Multiple linear, semi-log and log regression with interaction of the whole group were performed for statistical analysis.

RESULTS: PM10 concentrations at school were slightly lower (26.0 vs 27.7 µg/m3 P=3.41E-19) compared with exposure at home. Demographic parameters (age, gender), body mass index (BMI), systolic and diastolic blood pressures (SBP, DBP) were similar between lowest and top AP exposure groups. Carotid IMT was significantly thinner (0.439mm vs 0.453mm, P=1.75E-18) in students with lowest PM10 school exposure tertile compared with top tertile.

Lowest AP Tertile Top AP Tertile P-Values (Bonferroni (N=317) (N=316) adjustment)

PM10 (μg/m3) 22.94 29.87 9.22E-170
Age (yrs) 13.0 13.0 0.8274
Male (%) 37.2 39.9 0.5464
SBP (mmHg) 109.34 107.21 0.0085 (0.06)
DBP (mmHg) 63.00 61.73 0.0227 (0.14)
BMI 19.34 19.35 0.9616
Carotid IMT (mm) 0.439 0.453 1.75E-18

On multiple regression, age, gender and school AP exposure (PM10, NO2, CO, O3 and SO2) but not home AP exposure, were significantly related to carotid IMT, independent of health variables (F-value: 36.9 on 12 and 963 Degree of Freedom, p-value: < 2.2E-16). These variables account for 30.6% of variation in carotid IMT (Adjusted R-squared: 0.3061).

CONCLUSION: AP has an impact on early atherogenic process in young children, proposing a model for preventive intervention for atherosclerosis.
著者CHEUNG Kwan Yau, LI Man Chim Albert Martin, LO Leung Yau,CHOOK Ping, LEUNG Kwong Sak, LAO Xiangqian, LEUNG Yee, WOO Kam Sang
會議名稱25th Annual Scientific Congress of Hong Kong College of Cardiology
會議地點Sheraton Hong Kong Hotel & Towers

上次更新時間 2018-20-01 於 17:59