The regulations and role of circadian clock and melatonin in uterine receptivity and pregnancy—An immunological perspective
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AbstractDuring normal pregnancy, the mechanism by which the fetus escapes immunological rejection by the maternal womb remains elusive. Given the biological complexities, the immunological mechanism is unlikely to be simply an allograft response in acceptance or rejection of the early pregnancy. Circadian clock responsible for the mammalian circadian rhythm is an endogenously generated rhythm associated with almost all physiological processes including reproduction. There is now growing evidence to suggest that the circadian clocks are intricately linked to the immune system and pregnancy. When perturbed, the role of immune cells can be affected on maintaining the enriched vascular system needed for placentation. This alteration can be triggered by the irregular production of maternal and placental melatonin. Hence, the role of circadian rhythm modulators such as melatonin offers intriguing opportunities for therapy. In this review, we evaluate the complex interaction between the circadian clock and melatonin within the immune system and their roles in the circadian regulation and maintenance of normal pregnancy.
Acceptance Date04/05/2017
All Author(s) ListMan Gene Chi Wai, Zhang Tao, Chen Xiaoyan, Wang Jianzhang, Wu Fangrong, Liu Yingyu, Wang Chi Chiu, Cheong Ying, Li Tin Chiu
Journal nameAmerican Journal of Reproductive Immunology
Volume Number78
Issue Number2
Place of PublicationDenmark
Article numbere12715
LanguagesEnglish-United States
Keywordscircadian rhythms, immune response, melatonin, placenta, pregnancy

Last updated on 2021-20-09 at 23:29