Coronary artherosclerosis in psoriatic arthritis – a case control study
Refereed conference paper presented and published in conference proceedings

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AbstractIntroduction: The aim of this study was to evaluate the presence, burden and compositional differences of coronary plaque in patients with psoriatic arthritis (PsA) without symptoms or diagnosis of coronary artery disease (CAD) compared with controls.

Design and subjects: A total of 55 PsA patients underwent 64-slice coronary CT angiogram (CTA) and data from 55 age and gender matched control were retrived. Standardised American Heart Association 15-segment model was used for imaging analysis. Lesions were classified as noncalcified plaque (NCP), mixed (MP), and fully calcified plaque (CP).

Results: The mean age and sex (Male: 36 (65%) vs Female: 19 (35%) for both groups) of PsA patients (50±12 years) and controls (49±10 years) were similar. The proportion of PsA patients having any coronary plaque were numerically higher compared with controls (61.8% vs 47.3%, p=0.13), The prevalence of NCP appeared to be increased in PsA patients compared to controls (50.9% vs 34.5%, p=0.08). After patients were subdivided according to gender, female PsA patients have a significantly higher prevalence of NCP (9(47.4%) vs 3(15.8%), p=0.04). The increase in risk remained significant after adjusting for other risk factors (OR=6.0, 95% CI:4.1-34.3, p=0.04, table 1). With regards to PsA patients, disease duration was the only independent predictor for having NCP (OR=1.078,
95%CI=1.003-1.159, p=0.041) after adjusting for age and gender.

Conclusion: Female PsA patients were at a higher risk of developing NCP compared with controls. Inflammatory burden as reflected by the longer disease duration was probably the main driver for PsA patients to develop coronary atherosclerosis.
All Author(s) ListT.H. CHENG, K. T. WONG, J. SHEN, Q. SHANG, E. K. LI, L. S. TAM
Name of Conference18th Asia Pacific League of Associations for Rheumatology Congress (APLAR 2016)
Start Date of Conference26/09/2016
End Date of Conference29/09/2016
Place of ConferenceShanghai
Country/Region of ConferenceChina
Proceedings TitleInternational Journal of Rheumatic Diseases
Special Issue: Abstracts of the 18th Asia Pacific League of Associations for Rheumatology Congress (APLAR)
Year2016
Month9
Volume Number19
Issue NumberSuppl. S2
PublisherAsia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd
Pages9 - 9
LanguagesEnglish-United Kingdom

Last updated on 2021-17-01 at 00:20