Achieving remission and physical function in patients with early rheumatoid arthritis
Refereed conference paper presented and published in conference proceedings

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AbstractBackground: Patients with rheumatoid arthritis (RA) often develop functional disability. The aim of current treatment of RA is to achieve remission through tight control. However, the correlation between achieving remission and prevention of functional disability is not clearly evaluated in Asian population.

Method: Early RA patients with symptom onset of less than 2 years were recruited in this prospective cohort study. Remission was measured by Disease Activity Score 28 (DAS28) every 3 months. Functional disability was measured by Health Assessment Questionnaire (HAQ) at baseline and after follow-up for one year. HAQ score >0 at 1 year was defined as disability+.

Results: A total of 126 patients (53.78±13.69 years, 93[73.8%] female) were included. At 1 year, 62(49.2%) patients were classified as disability+. These patients were more likely to be female (51[82.3%]/42[65.6%], p=0.034), and had higher baseline HAQ (0.94±0.61/0.64±0.61, p=0.011) and baseline anxiety score (6.75±4.32/4.81±3.76, p=0.009) than patients without disability. During followup, disability+ patients were less likely to achieve at least one DAS remission (DAS28<2.6, 36[58.1%]/58[90.6%], p<0.001). The number of visits achieving DAS remission was also significantly less in disability+ patients throughout follow-up (1.29±1.49/2.66±1.45, p<0.001). After adjusting for age, sex, baseline HAQ and baseline anxiety score, at least one episode of DAS28 remission was independently associated with lower risk of disability+ (OR=0.13, 95%CI[0.42-0.40], p<0.001). Baseline higher HAQ was associated with disability+ (OR=2.52, 95%CI[1.26-5.06], p=0.009).

Conclusion: Early RA patients who achieved remission at least once within the first year of follow-up were less likely to develop functional disabilities.
All Author(s) ListH. M. LAM, M. L. YIP, I. C. W. YIM, V. K. L. LEE, K. Y. KWOK, C. C. MOK, L. S. TAM, HK CRYSTAL STUDY GROUP
Name of Conference18th Asia Pacific League of Associations for Rheumatology Congress (APLAR 2016)
Start Date of Conference26/09/2016
End Date of Conference29/09/2016
Place of ConferenceShanghai
Country/Region of ConferenceChina
Proceedings TitleInternational Journal of Rheumatic Diseases
Special Issue: Abstracts of the 18th Asia Pacific League of Associations for Rheumatology Congress (APLAR), 26–29 September 2016, Shanghai, China
Year2016
Month9
Volume Number19
Issue NumberSupplement S2
PublisherAsia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd
Pages208 - 208
LanguagesEnglish-United Kingdom

Last updated on 2020-01-12 at 00:08