Achieving SDAI Remission and healing of erosions in patients with early rheumatoid arthritis-A prospective HR-PQCT-based study
Refereed conference paper presented and published in conference proceedings

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AbstractObjectives: To assess whether achieving remission in patients with early rheumatoid arthritis (ERA) allows repair of existing bone erosions as measured by highresolution peripheral quantitative computed tomography (HR-pQCT).

Methods: A total of 30 ERA patients were enrolled. Changes in the size (maximal width, depth, volume) and marginal osteosclerosis (i.e bone density surrounding the erosion) of existing erosions at the second metacarpal-phalangeal joint (MCP2) were quantified using HRpQCT at baseline, 6 months and 12 months. Patients were subgrouped according to whether or not they achieved simplified disease activity score (SDAI) remission (SDAI< 3.3) at 12 months.

Results:12 (40%) patients achieved (Group 1) and 18 (60%) patients did not achieve (Group 2) SDAI remission at 12 months. At baseline, no significant differences in erosion size and marginal osteosclerosis were present between the two groups. Erosion volume decreased and marginal osteosclerosis increased in Group 1, but not in Group 2, between baseline and 12 months (Table 1). At 12 months, erosion volume remained significantly lower in Group 1 compared with Group 2.

Conclusion: In ERA patients who achieved SDAI remission at 12 months, HRpQCT revealed a reduction in erosion volume and an increase in marginal osteosclerosis not seen in those who did not achieve remission. HRpQCT shows healing changes in bone erosions in line with clinical SDAI remission.
All Author(s) ListJ. YUE, J. F. GRIFFITH, L. SHI, D. WANG, J. SHEN, P. WONG, E. K. LI, M. LI, T. K. LI, T. Y. ZHU, L. QIN, L. S. TAM
Name of Conference18th Asia Pacific League of Associations for Rheumatology Congress (APLAR 2016)
Start Date of Conference26/09/2016
End Date of Conference29/09/2016
Place of ConferenceShanghai
Country/Region of ConferenceChina
Proceedings TitleInternational Journal of Rheumatic Diseases
Special Issue: Abstracts of the 18th Asia Pacific League of Associations for Rheumatology Congress (APLAR)
Year2016
Month9
Volume Number19
Issue NumberSuppl. S2
PublisherAsia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd
Pages189 - 189
LanguagesEnglish-United Kingdom

Last updated on 2020-13-08 at 03:54