Probiotic Bacteria VSL#3 Alter Visceral Sensitivity and Mucosa-Associated Intestinal Microbiota in Patients With Irritable Bowel Syndrome
Refereed conference paper presented and published in conference proceedings


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AbstractBackground: In irritable bowel syndrome (IBS) visceral sensitivity is altered, the gut microbiota may be altered, and probiotic bacteria appear to be therapeutically effective. The effect of probiotic bacteria on visceral sensitivity and intestinal microbial communities in IBS is unknown. We characterised the mucosa-associated microbiota, and determined the clinical and microbiological effects of orally administered probiotic bacteria in patients with IBS in an open-label pilot study. Methods: Mucosal microbiota from rectal biopsies of IBS and control subjects were assessed on the V1 and V2 variable regions of the 16S ribosomal RNA gene amplified using 454 pyrosequencing. Clinical symptoms, rectal sensitivity and changes in mucosal microbiota were assessed in IBS patients before and after treatment with probiotic mix VSLAN
All Author(s) ListNg SC, Lam FC, Lam TY, Chan Y, Law WTW, Tse C, Kamm MA, Sung JJ, Chan FKL, Wu JC
Name of ConferenceDigestive Disease Week (DDW)
Start Date of Conference19/05/2012
End Date of Conference22/05/2012
Place of ConferenceSan Diego
Country/Region of ConferenceUnited States of America
Proceedings TitleGASTROENTEROLOGY
Year2012
Month5
Volume Number142
Issue Number5, Suppl. 1
PagesS391 - S391
ISSN0016-5085
LanguagesEnglish-United States

Last updated on 2021-08-12 at 00:11