Colonoscopic Screening in Siblings of Patients With Advanced Neoplasm: A Prospective Case-Control Study
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AbstractBackground: The risk of developing colorectal neoplasia among siblings of individuals with advanced neoplasm (AN) is unclear, and screening strategies remain controversial in this population. This case-control study aimed to determine the risk of colorectal neoplasia using colonoscopic screening in asymptomatic siblings of subjects with AN (cases) compared with colonoscopic screening in asymptomatic siblings of subjects with normal colonoscopy (controls). Methods: A colonoscopy was offered to siblings of 200 subjects with AN (adenomas > 10mm size, >25% villous features, severe dysplasia or carcinoma-in-situ, between 40-70 years of age. Among them, 188 were matched for age (+/- 3 years) and sex with two controls each (n=369). Controls subjects were asymptomatic siblings to subjects with normal colonosopic findings, who underwent a colonoscopy. Subjects with hereditary colorectal cancer syndromes were excluded. Results: The mean age of case and control subjects was 56 and 55 years old, respectively (48% male in both groups). The prevalence of AN or cancers was 11.7% and 3.3% [Matched odds ratio (mOR) 3.43; 95% CI, 1.69-6.96; p=0.001] and the prevalence of any colorectal neoplasia was 40.4% and 21.4% (mOR 2.29; 95% CI, 1.55 - 3.38; p<0.001), in cases and controls, respectively. In a multivariate analysis, a history of AN in siblings was associated with an increased risk of AN (mOR 2.96; 95% CI, 1.42 - 6.2) and any colorectal neoplasia (mOR 2.43; 95% CI, 1.64 - 3.61) after adjusted for aspirin use and alcohol consumption. Female sex in the index case, (mOR 6.55; 95% CI, 1.83 - 23.44) index case <60 years old (mOR, 3.07; 95% CI, 1.28 - 7.36) and index case with distally located AN (mOR, 5.18; 95% CI, 1.66 - 16.15) were associated with a higher risk of AN. Conclusions: Siblings of patients with AN have an increased risk of developing colorectal neoplasia. This high risk group should be offered screening colonoscopy. (Table Presented).
All Author(s) ListNg SC, Hui A, Suen BY, Tse YK, Ki ELL, Ching J, Wu JC, Sung JJ, Chan FKL, Lau JY
Name of ConferenceDigestive Disease Week (DDW)
Start Date of Conference19/05/2012
End Date of Conference22/05/2012
Place of ConferenceSan Diego
Country/Region of ConferenceUnited States of America
Proceedings TitleGASTROENTEROLOGY
Year2012
Month5
Volume Number142
Issue Number5, Suppl. 1
PagesS770 - S770
ISSN0016-5085
LanguagesEnglish-United States

Last updated on 2021-08-12 at 00:11