Low-dose aspirin cannot prevent colorectal cancer: A meta-analysis of randomized controlled trials
Refereed conference paper presented and published in conference proceedings


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AbstractIntroduction Aspirin reduces the risk of various cancers, but its use as a prevention for colorectal cancer (CRC) remains controversial. Materials and methods Randomized controlled trials of aspirin for the prevention of colorectal neoplasia from 1950 to 2010 were identified. Meta-analyses were performed to combine the overall effect. Results Five randomized-controlled trials that recruited a total of 70,656 subjects and 832 cases of CRC were included. The mean treatment duration was 7.83 years (range, 2.73-10.1 years), and the use of daily aspirin ranged from 50 mg to 1200 mg. Overall, the use of aspirin was not associated with a reduced risk of CRC (RR 0.94; 95% CI 0.82-1.07). In subgroup analyses, aspirin failed to reduce the risk of CRC in subjects taking aspirin less than 100 mg daily, or in subjects with treatment duration less than 5 years. Aspirin reduced CRC risk significantly only in subjects with high dose-years (>1000 mg-years) of aspirin (RR 0.74; 95% CI, 0.57-0.97) and in subjects taking at least 150 mg daily for a mean duration of five years over a latency of ten years (RR 0.71; 95% CI, 0.54-0.93). Conclusion This meta-analysis shows that low dose or short-term treatment with aspirin does not reduce the incidence of CRC. The protective effect against CRC requires daily dosage of aspirin no less than 150 mg for at least five years of regular medication with a latency of about 10 years.
All Author(s) ListTsoi KK, Ng SC, Hirai HW, Chan FK, Sung JJ
Name of ConferenceAsia Pacific Digestive Week
Start Date of Conference19/09/2010
End Date of Conference22/09/2010
Place of ConferenceKuala Lumpur
Country/Region of ConferenceMalaysia
Proceedings TitleJOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
Year2010
Month9
Volume Number25
Issue NumberSuppl. 2
PagesA16 - A17
ISSN0815-9319
LanguagesEnglish-United States

Last updated on 2021-05-03 at 00:00