The Effects of Dysphagia on Quality of Life in Post-irradiated Nasopharyngeal Cancer Patients
Refereed conference paper presented and published in conference proceedings

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AbstractIntroduction: Irradiation-treated nasopharyngeal cancer (NPC) survivors with dysphagia have significant deterioration in their quality of life (QOL). Intensity-modulated radiotherapy (IMRT) is controversial in its effectiveness in reducing the prevalence of dysphagia in these patients. Previous QOL studies obtained swallowing data from self-reported severity ratings1 rather than objective physiological measurement and we aimed to investigate the severity of dysphagia through physiological assessments, and the factors affecting the QOL of IMRT-treated long-term NPC survivors in Hong Kong.
Methods: This was a cross-sectional study of 163 irradiation-treated NPC patients recruited from Prince of Wales Hospital. All participants underwent fiberoptic endoscopic evaluation of swallowing (FEES). Swallowing performance was scored using the penetration-aspiration scale (PAS)2. Quality-of-life profile was collected using the Functional Assessment of Cancer Therapy - Nasopharyngeal (FACT-NP)3. Linear regression analysis was performed to identify significant factors that predict QOL.
Results: Fourty nine (30%) patients demonstrated deep penetration or aspiration (i.e. PAS score>3) on at least one food consistency during FEES. Both PAS score (p<.001) and education level (p=.003) were identified as significant predictors for QOL in treated NPC patients. A higher PAS score resulted in a lower QOL, whilst a higher education level predicted a higher QOL. Gender, age, stage of disease, radiation technique, time elapsed since irradiation had no significant effect on QOL.
Conclusion: Despite the advancement in radiation technique for the treatment of NPC over the past decade, dysphagia remained a major clinical problem for NPC survivors, and adversely affects their quality of life. More effort is needed to prevent or delay the occurrence of dysphagia and its related complications.
All Author(s) ListD.T.H. Cheng, M.C.F. Tong, K.Y.S. Lee
Name of Conference6th ESSD Congress Milan - Deglutology: from science to clinical practice
Start Date of Conference14/10/2016
End Date of Conference15/10/2016
Place of ConferenceMilan, Italy
Country/Region of ConferenceItaly
Proceedings TitleDysphagia
Volume Number32
Issue Number1
Place of PublicationNew York, USA
Pages174 - 207
LanguagesEnglish-United States
KeywordsDysphagia, quality of life, nasopharyngeal cancer, radiotherapy, penetration-aspiration

Last updated on 2020-05-08 at 02:40