Comparison of Detrusor Muscle Sampling Rate in Monopolar and Bipolar Transurethral Resection of Bladder Tumor: A Randomized Trial
Publication in refereed journal

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其它資訊
摘要Purpose:
Our aim was to investigate the detrusor muscle sampling rate after monopolar versus bipolar transurethral resection of bladder tumor (TURBT).
Methods:
This was a single-center, prospective, randomized, phase III trial on monopolar versus bipolar TURBT. Baseline patient characteristics, disease characteristics and perioperative outcomes were compared, with the primary outcome being the detrusor muscle sampling rate in the TURBT specimen. Multivariate logistic regression analyses on detrusor muscle sampling were performed.
Results:
From May 2012 to December 2015, a total of 160 patients with similar baseline characteristics were randomized to receive monopolar or bipolar TURBT. Fewer patients in the bipolar TURBT group required postoperative irrigation than patients in the monopolar TURBT group (18.7 vs. 43%; p = 0.001). In the whole cohort, no significant difference in the detrusor muscle sampling rates was observed between the bipolar and monopolar TURBT groups (77.3 vs. 63.3%; p = 0.057). In patients with urothelial carcinoma, bipolar TURBT achieved a higher detrusor muscle sampling rate than monopolar TURBT (84.6 vs. 67.7%; p = 0.025). On multivariate analyses, bipolar TURBT (odds ratio [OR] 2.23, 95% confidence interval [CI] 1.03–4.81; p = 0.042) and larger tumor size (OR 1.04, 95% CI 1.01–1.08; p = 0.022) were significantly associated with detrusor muscle sampling in the whole cohort. In addition, bipolar TURBT (OR 2.88, 95% CI 1.10–7.53; p = 0.031), larger tumor size (OR 1.05, 95% CI 1.01–1.10; p = 0.035), and female sex (OR 3.25, 95% CI 1.10–9.59; p = 0.033) were significantly associated with detrusor muscle sampling in patients with urothelial carcinoma.
Conclusions:
There was a trend towards a superior detrusor muscle sampling rate after bipolar TURBT. Further studies are needed to determine its implications on disease recurrence and progression.
著者Jeremy Yuen-Chun Teoh, Eddie Shu-Yin Chan, Siu-Ying Yip, Ho-Man Tam, Peter Ka-Fung Chiu, Chi-Hang Yee, Hon-Ming Wong, Chi-Kwok Chan, Simon See-Ming Hou, Chi-Fai Ng
期刊名稱Annals of Surgical Oncology
出版年份2017
月份5
卷號24
期次5
出版社SPRINGER
頁次1428 - 1434
國際標準期刊號1068-9265
電子國際標準期刊號1534-4681
語言英式英語
Web of Science 學科類別Oncology;Surgery;Oncology;Surgery

上次更新時間 2021-15-01 於 01:02