Baseline AMH is associated with ovulation induction dose and ovulatory response and predicts ovulation rate in women with Polycystic Ovary Syndrome
Refereed conference paper presented and published in conference proceedings


摘要Study question: To investigate association between baseline AMH levels, ovulatory response to ovulation induction dose among women enrolled in the Polycystic Ovary Syndrome Acupuncture and Clomiphene Trial (PCOSAct).
Summary answer: Higher baseline AMH is negatively associated with lower ovulatory response and requires higher ovulation induction dose to achieve ovulation in women with PCOS.
What is known already: AMH plays an inhibitory role in follicular development and recruitment, contributing to follicular arrest.AMH also reduces aromatase activity and sensitivity of follicles to FSH stimulation. Therefore, elevated serum AMH may have higher threshold response to ovulation induction and affect pregnancy outcome in women with PCOS.
Study design, size, duration: A secondary analysis of the Polycystic Ovary Syndrome Acupuncture and Clomiphene Trial (PCOSAct), a large-sample, multi-center, randomized placebo-controlled clinical trial conducted from 2012
to 2015 in mainland China.1000 PCOS women were randomly assigned in a 1:1:1:1 ratio, to receive true acupuncture or control acupuncture integrated with clomiphene or placebo clomiphene for up to four cycles treatment. Baseline serum AMH concentrations were measured by AnshLabs AL-105-I Ultra-Sensitive AMH/MIS ELISA kits.
Participants/materials, setting, methods: Logistic regression models to test association of demographic, metabolic and biochemical profiles with ovulation, conception, pregnancy and live birth adjusted by the interventions.OR and 95% CI to compare ovulation induction dose and ovulatory response according to the logistic models. ROC to confirm prediction values of AMH for ovulation. Kaplan–Meier curve to compare time to ovulation in the four quartiles.
Main results and the role of chance: Age, BMI(body mass index), WHR (whist to hip ratio),duration of infertility,baseline AMH,progesterone, total testosterone, E2(estradiol), SHBG (sex hormone-binding globulin)and glucose were significantly associated with ovulation, but not conception, pregnancy and live birth. AMH levels were significantly higher among women who did not achieved ovulation than those women who achieved ovulation both overall and within intervention groups (P < .0001) and required higher ovulation induction dose to achieve ovulation. Baseline AMH significantly predicted ovulation
著者Wu Q, Li J, Wu XK, Xie L, Ng EH, Mol BW, Wang CC
會議名稱The 33rd Annual Meeting of the European Society of Human Reproduction and Embryology (ESHRE)
會議論文集題名Human Reproduction
出版社Oxford Open
頁次i473 - i474

上次更新時間 2021-16-09 於 01:51