Exposure to 2,2',4,4'-tetrabromodiphenyl ether at late gestation modulates placental signaling molecules in the mouse model
Publication in refereed journal

香港中文大學研究人員
替代計量分析
.

其它資訊
摘要Polybrominated diphenyl ethers (PBDEs) are flame retardants generally employed in manufacturing household items. Surface water may remove and carry these chemicals to the drainage upon disposal of the items, and ultimately the chemicals enter our food chain. 2,2',4,4'-Tetrabromodiphenyl ether (BDE47) is a PBDE congener commonly found in contaminated seafood. The placenta is the site of nutrient exchange and is responsible for reproductive hormone secretion during pregnancy. In the present study, pregnant ICR mice were given p.o. daily doses of BDE-47 at 0, 036, 3.6, 36 mg/kg for 4 days (from E13.5 to E16.5). Compared to the control group, increased rates of stillborn and low birth weight were observed in mice treated with 36 mg BDE-47/kg. Plasma testosterone and progesterone levels were reduced in mice treated with 36 mg BDE-47/kg. In addition, the group treated with 3.6 mg/kg of BDE-47 displayed decreased growth hormone (Gh) peptide expression in the placental tissue extracted at E17.5. As this peptide stimulates growth, the expression pattern might suggest compromised fetal development. Further analysis indicated that mitogen-activated protein kinases (MAPK) were activated in the placental tissue of the BDE-47-treatment groups. The activation of these signaling molecules might affect the hormonal and other physiological functions in the tissue.
著者Zhu Y, Tan YQ, Leung LK
期刊名稱Chemosphere
出版年份2017
月份8
卷號181
頁次289 - 295
國際標準期刊號0045-6535
電子國際標準期刊號1879-1298
語言英式英語
關鍵詞BDE-47,MAPK,Placental tissue
Web of Science 學科類別Environmental Sciences;Environmental Sciences & Ecology

上次更新時間 2020-12-08 於 02:45