Particle size effect of curcumin nanosuspensions on cytotoxicity, cellular internalization, in vivo pharmacokinetics and biodistribution
Publication in refereed journal

香港中文大學研究人員
替代計量分析
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其它資訊
摘要This study aimed to investigate the particle size effect on bioactivity, cellular internalization and bioavailability of curcumin (CUR) nanosuspension (CUR-NS). CUR-NSs of different particle sizes were prepared by two different anti-solvent precipitation methods. CUR-NS with the smallest size showed similar in vitro anticancer activity and bioavailability to the CUR solution, whereas nanosuspensions of larger particle sizes displayed higher in vitro cellular internalization and cytotoxicity, as well as higher in vivo AUC and slower clearance rate after i. v. administration in rats. CUR solution and different sized CUR-NSs reached the highest concentrations in the lung, followed by liver and spleen while the lowest concentration was observed in the brain after i. v. administration in mice. Specifically, CUR-NS of 70 nm accumulated more in the brain, whereas CUR-NS of 200 nm accrued more in liver and spleen. CUR-NS of 20 nm displayed no significant biodistribution difference compared with CUR solution in all tissues. (C) 2016 Elsevier Inc. All rights reserved.
出版社接受日期17.11.2016
著者Bi C, Miao XQ, Chow SF, Wu WJ, Yan R, Liao YH, Chow AHL, Zheng Y
期刊名稱Nanomedicine: Nanotechnology, Biology and Medicine
出版年份2017
月份4
日期1
卷號13
期次3
出版社ELSEVIER SCIENCE BV
頁次943 - 953
國際標準期刊號1549-9634
電子國際標準期刊號1549-9642
語言英式英語
關鍵詞Curcumin nanosuspensions, Particle size, Multi-inlet vortex mixer, Anticancer Activity, Pharmacokinetics, Biodistribution
Web of Science 學科類別Nanoscience & Nanotechnology;Medicine, Research & Experimental;Science & Technology - Other Topics;Research & Experimental Medicine

上次更新時間 2020-13-09 於 00:57