Circulating microRNAs as biomarkers of delayed cerebral infarction after aneurysmal subarachnoid hemorrhage
Refereed conference paper presented and published in conference proceedings


Times Cited
Web of Science0WOS source URL (as at 14/10/2020) Click here for the latest count
Altmetrics Information
.

Other information
AbstractBackground and Purpose:
Delayed cerebral infarction (DCI) is a major cause of morbidities after aneurysmal subarachnoid hemorrhage (SAH) and typically starts at day 4 to 7 after initial hemorrhage. Multiple mechanisms have been proposed for the development of DCI, and these had held back the development of diagnostic biomarkers and therapeutics strategy. MicroRNAs (miRNA) play important role in posttranscriptional gene expression control, and distinctive patterns of circulating miRNA changes have been identified for some diseases. We aimed to establish miRNA indicators to characterize SAH patients with DCI as compared to those without DCI.

Methods:
Circulating miRNAs were collected on day 7 post-SAH in a 60-subject cohorts namely the healthy controls (N¼20), SAH patients with DCI (N¼20) and SAH patients without DCI (N¼20). We developed a bioinformatics pipeline to integrate multi-miRNAs classifier approach with the LASSO regression model to classify SAH patients with and
without DCI.

Results:
In the 28 dysregulated miRNAs associated with DCI and SAH, we found that a four-miRNAs indicator (miR-4532, miR-4463, miR-1290, and miR-4793) could differentiate SAH patients with DCI from without DCI with an AUC of 100% (95% CI: 1.000 – 1.000, p<0.001). The four miRNAs can also distinguish SAH patients with or without DCI from healthy controls with an AUC of 99.3% (95% CI: 0.977 - 1.000, p<0.001) and of 82.0% (95% CI: 0.685 0.955, p<0.001) respectively.

Conclusion:
We developed a four-miRNA-based classifier system with the LASSO Cox regression model to differentiate SAH patients with or without DCI.
All Author(s) ListGeorge Kwok Chu Wong
Name of Conference28th International Symposium on Cerebral Blood Flow, Metabolism and Function / 13th International Conference on Quantification of Brain Function with PET (BRAIN & BRAIN PET 2017)
Start Date of Conference01/04/2017
End Date of Conference04/04/2017
Place of ConferenceBerlin, Germany
Country/Region of ConferenceGermany
Proceedings TitleJournal of Cerebral Blood Flow & Metabolism
Series TitlePoster Viewing Session V
Number in SeriesPS05-080
Year2017
Month4
Volume Number37
Issue Number1_suppl
PublisherSAGE
Pages426 - 427
ISSN0271-678X
eISSN1559-7016
LanguagesEnglish-United Kingdom
Keywordsbiomarkers, delayed cerebral infarction, aneurysmal subarachnoid hemorrhage

Last updated on 2020-15-10 at 02:41