Multi-target Pharmacological Effects of Platycodin D
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AbstractPlant secondary metabolites are considered as a valuable source to identify promising lead compounds for developing novel drugs. Platycodin D is regarded as one of the major bioactive compounds from medicinal plant Platycodon grandiflorum, which attracts growing interests from researchers these years due to its potent effects. The present paper reviews the latest knowledge of biological and pharmacological activities of platycodin D. In vitro and in vivo experimental evidences have revealed that platycodin D demonstrates multiple pharmacological properties including anti-oxidative, anti-inflammatory, anticancer, anti-obesity, anti-diabetes and hepatoprotective effects. The underlying mechanisms of multiple therapeutic functions of platycodin D are very likely associated with its antiinflammatory and antioxidant nature whereas low bioavailability should be considered in drug development.
All Author(s) ListZhong-Rong Zhang, Chun Wai Chan
Journal nameMini-Reviews in Organic Chemistry
Volume Number14
Issue Number6
PublisherBentham Science Publishers
LanguagesEnglish-United Kingdom
KeywordsPlatycodin D, Platycodon grandiflorum, Antioxidant, Anti-inflammation, Anticancer, anti-obesity, anti-diabetes, hepatoprotection

Last updated on 2021-14-09 at 00:54