Characterization of the Human 36-kDa Carboxyl Terminal LIM Domain Protein (hCLIM1)
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摘要We characterized a human cDNA clone encoding a 36‐kDa carboxyl terminal LIM domain protein with a PDZ domain at the amino terminal. This full‐length cDNA clone has a predicted open reading frame (ORF) of 329 amino‐acid residues. The ORF of this cDNA encodes the human homolog of rat CLP36, and the putative protein is named human 36‐kDa carboxyl terminal LIM domain protein (hCLIM1, nomenclature approved by the HUGO/GDB Nomenclature Committee). The hCLIM1 probe was used to hybridize with poly(A)+ RNA of various human tissues. Strong signals were detected in heart and skeletal muscle; moderate signals were detected in spleen, small intestine, colon, placenta, and lung; weaker levels were detected in liver, thymus, kidney, prostate, and pancreas; and no observable signals were detected in brain, testis, ovary, and peripheral blood leukocytes. The hCLIM1 gene was studied by fluorescence in situ hybridization (FISH), somatic cell hybrid analysis, and radiation hybrid mapping, and it is located at the human chromosome 10q26.
著者KOTAKA Masayo, NGAI Sai Ming, GARCIA-BARCELO Merce, TSUI Kwok Wing, FUNG Kwok Pui, LEE Cheuk Yu, WAYE Mary Miu Yee
期刊名稱Journal of Cellular Biochemistry
出版年份1999
月份2
日期1
卷號72
期次2
頁次279 - 285
國際標準期刊號0730-2312
語言英式英語

上次更新時間 2020-04-08 於 01:16