Multiple Comparisons with Two Controls for Ordered Categorical Responses
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AbstractIn clinical studies, ordered categorical responses are common. To compare the efficacy of several treatments with a control for ordinal responses, the normal latent variable model has recently been proposed. This approach conceptualizes the responses as manifestations of an underlying continuous normal variable. In this paper, we extend this idea to develop the multiple comparison method for use when there are two controls in the clinical trial. The proposed method is constructed such that the familywise type I error rate is controlled at a pre-specified level. In addition, for a given level of test power, the procedure to evaluate the required sample size is provided. The proposed testing procedure is also illustrated by an example from a clinical study.
All Author(s) ListYANG Ping, CHEUNG Siu Hung, POON Wai Yin
Name of Conference2015 Joint Statistical Meetings
Start Date of Conference08/08/2015
End Date of Conference13/08/2015
Place of ConferenceSeattle
Country/Region of ConferenceUnited States of America
Proceedings Title2015 Joint Statistical Meeting
PublisherJoint Statistial Meeting
Place of PublicationUnited States of America, Seattle
LanguagesEnglish-United Kingdom

Last updated on 2019-30-10 at 15:21