Mg-based Biometal for orthopaedic Applications-Opportunities & Challenges
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AbstractIt is known that magnesium (Mg) is the eighth most common element in the crust of the earth and now attracts great
attention to become biodegradable or biocorrosive medical implants for both cardiovascular and orthopaedic
applications.

In orthopaedics, Mg and its alloys are mainly considered suitable for degradable bone implants with good initial
stability that avoid a second surgical procedure to remove the temporary metallic parts for fixation after the tissue has sufficiently healed, apart from lowering overall associated health care costs. Safety concerns are also raised although Mg dissolution is unlikely to have adverse or side effects since Mg is the fourth most plentiful cation in the human body, including involvement in the formation of biological crystal apatite; it is also a co-factor for many enzymes and stabilizes the structures of DNA and RNA; beneficial from a physiological standpoint, since Mg deficiencies in human body will result in disorders of metabolic organs and cardiovascular system as well.

The author’s group is conducting R&D of orthopaedic implants, in collaboration with biomaterial scientists for developing Mg and its alloys as biocorrosive orthopaedic implants and investigating their bone stimulation effects
physiologically and biologically using both in vitro and in vivo preclinical experimental models. Human pilot or Phase I
studies are also conducted to investigate its biosafety as well as its efficacy for adequate orthopaedic indications.

The presentation generated from this R&D program on Mg or its alloys is based on a translational R&D model and roadmap, i.e. from Observations to Mechanisms and then to Proof-ofConcept before clinical tests, followed by clinical trials. Testing standards and guidelines are also essential for this translational roadmap and the author’s group has also been working on necessary modification for current ISO standard for testing cytotoxicity relevant for biodegradable implants.
All Author(s) ListQIN Ling
Name of Conference21th Annual Conference of the Australian and New Zealand Orthopaedic Society (ANZORS)
Start Date of Conference02/10/2016
End Date of Conference04/10/2016
Place of ConferenceAuckland
Country/Region of ConferenceNew Zealand
Year2016
Month10
LanguagesEnglish-United Kingdom

Last updated on 2018-18-01 at 08:34