Turmeric — Could It be a Multi-targeted Herb for Colorectal Cancer Adjuvant Therapy?
Refereed conference paper presented and published in conference proceedings


全文

其它資訊
摘要Turmeric is a medicinal herb in Asia and as dietary supplement in western countries. Its major active component, curcumin, has good reputation for chemopreventive effects in different cancers. However, poor oral bioavailability of curcumin hinders the wide clinical application of this compound. Our research group made attempts to advance the utilization of the herb turmeric. The presence of lipophilic components (a/b-and aromatic-turmerones) of turmeric was previously shown to facilitate the absorption of curcumin into human intestinal Caco-2 cells. Our recent findings suggested that oral bioavailability of curcumin could be enhanced when curcumin is present in turmeric ethanolic extract. Besides,the anti-proliferative activities of a/b-turmerones in human breast and colon cancer cells, as well as in vitro and in vivo anti-angiogenic activities of aromatic-turmerone have also been demonstrated. Hence, turmeric extract was anticipated to possess anti-tumor effects in colon tumor-bearing mice. In this study, the hypothesis has been verified that turmeric extract plus bevacizumab, a monoclonal antibody approved as first line therapy with chemotherapy in colon cancer, exerted noteworthy anti-tumor activities in human colon tumor-bearing mice. The anti-tumor and life span prolonging efficacies of turmeric extract were comparable to those of the first line hemotherapeutics, 5-fluorouracil, leucovorin and oxaliplatin (FOLFOX). Unlike FOLFOX treatment, the absence of hematologic side effects of turmeric extract treatment was another remarkable finding. In conclusion, our study demonstrated that turmeric ethanolic extract plus bevacizumab possessed potent anti-tumor effects in colon tumor-bearing mice without observable side effect, strongly suggesting the adjuvant use of turmeric in colorectal cancer. Acknowledgement: This work was financially supported by Food and Health Bureau HKSAR, Health and Health
Services Research Fund no. 09100341.
著者YUE Gar Lee Grace, KWOK Hin Fai, LEE Kin Ming, JIANG Lei, GAO Si, CHAN Kar Man, WONG Chun Wai, FUNG Kwok Pui, LEUNG Ping Chung, ZUO Zhong, LAU Bik San Clara
會議名稱Joint Meeting of the GP-TCM Research Association, The TCM Chemistry Specialty Committee and The TCM Pharmaceutical Analysis Specialty Committee of the World Federation of Chinese Medicine Societies
會議開始日12.07.2015
會議完結日15.07.2015
會議地點Mons
會議國家/地區比利時
會議論文集題名World Journal of Traditional Chinese Medicine
出版年份2015
月份10
卷號1
期次4
出版地Belgium, Mons
頁次74 - 75
語言英式英語

上次更新時間 2018-04-05 於 12:09