Photodynamic Therapy
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AbstractPhotodynamic therapy (PDT) is a clinically established treatment modality for a range of cancers. It utilizes the combined action of photosensitizer, light, and molecular oxygen to generate reactive oxygen species (ROS), particularly singlet oxygen, to eradicate malignant cells and tissues. The therapeutic outcome depends largely on the performance of the photosensitizer. For cancer treatment, only a few PDT drugs, including porfimer sodium, temoporfin, and aminolevulinic acid, have been clinically approved. Unfortunately, they still suffer from a number of drawbacks. As a result, development of new generations of photosensitizers that are more efficient and tumor selective, have a wider scope of action, and produce less side effect is under intensive investigation. In addition, various approaches have been actively explored to enhance the tumor-targeting property of photosensitizers. It is commonly believed that PDT exerts its antitumor effects through three different biological mechanisms. Firstly, the ROS generated through the photosensitization process can trigger apoptotic or necrotic response, leading to direct tumor cell death. Secondly, the photodynamic action can target the blood vessels so as to block the nutrient and oxygen supplies to the rapidly proliferating tumor cells. Finally, PDT can also enhance antitumor immunity which is important not only in killing the tumor cells but also in preventing recurrence. The treatment efficacy of PDT can further be improved in combination therapy where it is used together with drugs that are cytotoxic, anti-angiogenic, or immunogenic. This chapter aims to give an overview of the principle and development of this innovative approach for cancer treatment.
All Author(s) ListFONG Wing Ping, YEUNG Hing Yuen, LO Pui Chi, NG Kee Pui Dennis
All Editor(s) ListAaron Ho-Pui Ho, Donghyun Kim, Michael G. Somekh
Book titleHandbook of Photonics for Biomedical Engineering
Detailed descriptioned. by Aaron H.-P. Ho, Donghyun Kim, Michael G. Somekh.
PublisherSpringer Netherlands
Pages657 - 681
LanguagesEnglish-United Kingdom
KeywordsPhotodynamic Therapy, Photosensitizer, Tumor Targeting

Last updated on 2021-16-09 at 01:13