The role of 25OHD and 1,25OHD status in determining quadriceps strength and neuromuscular function in patients after anterior cruciate ligament reconstruction
Refereed conference paper presented and published in conference proceedings
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摘要Introduction: Quadriceps weakness persists after anterior cruciate ligament reconstruction (ACLR). Previously, we found 25-hydroxyvitamin D (25OHD) deficiency was associated with poorer quadriceps strength after ACLR. There is no literature investigating the role of 1,25 dihydroxyvitamin D (1,25(OH) 2D) on muscle mass. It is important to establish which marker of vitamin D (VitD) status is better correlated with clinical outcomes after ACLR.
Methods: Patients with ACLR were recruited. Assessments including serum 25OHD and 1,25(OH) 2D level, quadriceps strength, rate of torque development (RTD) and central activation ratio (CAR) were performed. The ratio of difference between the injured limb and uninjured limb on the uninjured limb was used to do the Spearman rank correlation analysis. Independent t-test was used to do subgroup analysis to compare results between different VitD status.
Results: Twenty-five patients were enrolled. The serum 25OHD level had moderate correlations with RTD0-50 and RTD100-200 difference between two limbs (r=0.68, p=0.04; and r=0.79, p=0.01). When divided into 25OHD deficiency plus 1,25(OH)2D non-deficiency group and 25OHD non-deficiency plus 1,25(OH)2D non-deficiency group, the deficiency group showed poorer muscle strength (p=0.029) and worse RTD100-200 and CAR (p=0.039 and p=0.013).
Discussion and Conclusion: 25OHD level was associated with the quadriceps contraction ability and showed a trend of correlation with maximal strength and the voluntary activation ability. Patients with 25OHD deficiency and 1,25(OH)2D non-deficiency showed poorer quadriceps strength, ability of contraction and voluntary activation. The findings of this study suggest that 25OHD and 1,25(OH)2D test play a role in determining quadriceps strength and neuromuscular functions in patients after ACLR.
Methods: Patients with ACLR were recruited. Assessments including serum 25OHD and 1,25(OH) 2D level, quadriceps strength, rate of torque development (RTD) and central activation ratio (CAR) were performed. The ratio of difference between the injured limb and uninjured limb on the uninjured limb was used to do the Spearman rank correlation analysis. Independent t-test was used to do subgroup analysis to compare results between different VitD status.
Results: Twenty-five patients were enrolled. The serum 25OHD level had moderate correlations with RTD0-50 and RTD100-200 difference between two limbs (r=0.68, p=0.04; and r=0.79, p=0.01). When divided into 25OHD deficiency plus 1,25(OH)2D non-deficiency group and 25OHD non-deficiency plus 1,25(OH)2D non-deficiency group, the deficiency group showed poorer muscle strength (p=0.029) and worse RTD100-200 and CAR (p=0.039 and p=0.013).
Discussion and Conclusion: 25OHD level was associated with the quadriceps contraction ability and showed a trend of correlation with maximal strength and the voluntary activation ability. Patients with 25OHD deficiency and 1,25(OH)2D non-deficiency showed poorer quadriceps strength, ability of contraction and voluntary activation. The findings of this study suggest that 25OHD and 1,25(OH)2D test play a role in determining quadriceps strength and neuromuscular functions in patients after ACLR.
著者Sunnie Tin-Ching Lam, Michael Tim-Yun Ong, Xiaomin Lu, Chi-Yin Choi, Daniel Kam-Wah Mok, Jonathan Patrick Ng, Patrick Shu-Hang Yung
會議名稱The HKOA 43rd Annual Congress of The Hong Kong Orthopaedic Association
會議開始日04.11.2023
會議完結日05.11.2023
會議地點Hong Kong
會議國家/地區香港
出版年份2023
月份11
出版社Hong Kong Academy of Medicine Press
出版地Hong Kong
頁次67 - 67
語言美式英語
