The relationship between bile acids, vitamin D and muscle function in patients with knee OA
Refereed conference paper presented and published in conference proceedings
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摘要Background: Vitamin D influences the incidence and progression of knee osteoarthritis. Recent studies indicated that gut microbiota (GM) diversity has an impact on overall bile acid levels, which in turn affects the activation of vitamin D and its role in regulation of muscle functions. Limited studies have investigated the relationships between bile acid and musculoskeletal functions. This study aimed to compare the bile acids, muscle strength and function between normal and deficient Vitamin D levels.
Methods: Vitamin D status was measured by serum 25-hydroxyvitamin D level (25(OH)D) and categorized into two groups: Vitamin D-deficient (G1, n=36, 15.9 ± 3.3 ng/mL) and normal Vitamin D groups (G2, n=27, 36.1 ± 5.7 ng/mL).
Primary and secondary bile acids were measured. Hand-held dynamometer was used to assess isometric knee muscle strength. Muscle function was evaluated using 6 meter gait speed test and chair-to-stand test. Independent t-test was used to compare all the parameters in two groups.
Results: Vitamin D-deficient group was shown to have significantly lower muscle strength compared with normal vitamin D group (p<0.05). Vitamin D-deficient group also had significantly higher BMI (p=0.031). Compared with the normal vitamin D group, primary and secondary bile acids were found to be 46% and 15% lower in vitamin D deficient group, respectively (p=0.211, p=0.37).
Conclusion: Vitamin D deficiency patients have worse knee muscle strength and a tendency for lower bile acids. We recommend vitamin D supplement as a routine treatment for OA knee patients. Interventions to improve bile acids may also improve the activation of Vitamin D activity.
Methods: Vitamin D status was measured by serum 25-hydroxyvitamin D level (25(OH)D) and categorized into two groups: Vitamin D-deficient (G1, n=36, 15.9 ± 3.3 ng/mL) and normal Vitamin D groups (G2, n=27, 36.1 ± 5.7 ng/mL).
Primary and secondary bile acids were measured. Hand-held dynamometer was used to assess isometric knee muscle strength. Muscle function was evaluated using 6 meter gait speed test and chair-to-stand test. Independent t-test was used to compare all the parameters in two groups.
Results: Vitamin D-deficient group was shown to have significantly lower muscle strength compared with normal vitamin D group (p<0.05). Vitamin D-deficient group also had significantly higher BMI (p=0.031). Compared with the normal vitamin D group, primary and secondary bile acids were found to be 46% and 15% lower in vitamin D deficient group, respectively (p=0.211, p=0.37).
Conclusion: Vitamin D deficiency patients have worse knee muscle strength and a tendency for lower bile acids. We recommend vitamin D supplement as a routine treatment for OA knee patients. Interventions to improve bile acids may also improve the activation of Vitamin D activity.
著者James Hong Yin Woo, Daniel Kam Wah Mok, Qian Wen Wang, Chi Yin Choi, Xin He, Jonathan Patrick Ng, Michael Tim Yun Ong, Patrick Shu Hang Yung
會議名稱The HKOA 43rd Annual Congress of The Hong Kong Orthopaedic Association
會議開始日04.11.2023
會議完結日05.11.2023
會議地點Hong Kong
會議國家/地區香港
出版年份2023
月份11
出版社Hong Kong Academy of Medicine Press
出版地Hong Kong
頁次61 - 61
語言美式英語
