Mg-containing hybrid interference screw promotes the healing of ACL reconstruction
Refereed conference paper presented and published in conference proceedings
香港中文大學研究人員
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摘要Introduction: Magnesium (Mg) and alloys have been recognized as potential biodegradable materials in anterior cruciate ligament (ACL) reconstruction due to promising effects on osteogenesis, angiogenesis, and tissue regeneration. However, one of the obstacles limiting the application of pure magnesium implant in clinic is that mechanical support is impaired at the rapid degradation phase after implanted in vivo. We innovatively designed a Mg-containing hybrid interference screw to maintain the mechanical strength while make good use of the biological effects of Mg.
Methods: Twenty-four skeletally mature Chinese mountain goats were divided into control group and Mg group, which were fixed with conventional titanium interference screw and Mg-containing hybrid interference screw to fix the graft in bone tunnel in ACL reconstruction, respectively.
Results: X-ray showed no signs of deformity or dislocation in both groups. For macroscopic evaluation, Mg group showed a relatively better outcome with more tissue connection and cartilage matrix at the tunnel aperture, which showed a higher Oswestry Arthroscopy Score than the control group at week 8 and week 16. HR-pQCT results showed greater BV/TV in the Mg group at both week 8 and week 16 compared to control group. At weeks 8 and 16, the tibial tunnel diameter in the Mg group was smaller than the control group.
Discussion and Conclusion: The innovative Mg-containing hybrid interference screw shows superior outcomes in terms of new bone formation around the bone tunnel than conventional interference screw, highlighting the great translational merit.
Methods: Twenty-four skeletally mature Chinese mountain goats were divided into control group and Mg group, which were fixed with conventional titanium interference screw and Mg-containing hybrid interference screw to fix the graft in bone tunnel in ACL reconstruction, respectively.
Results: X-ray showed no signs of deformity or dislocation in both groups. For macroscopic evaluation, Mg group showed a relatively better outcome with more tissue connection and cartilage matrix at the tunnel aperture, which showed a higher Oswestry Arthroscopy Score than the control group at week 8 and week 16. HR-pQCT results showed greater BV/TV in the Mg group at both week 8 and week 16 compared to control group. At weeks 8 and 16, the tibial tunnel diameter in the Mg group was smaller than the control group.
Discussion and Conclusion: The innovative Mg-containing hybrid interference screw shows superior outcomes in terms of new bone formation around the bone tunnel than conventional interference screw, highlighting the great translational merit.
著者Yuantao Zhang, Lizhen Zheng, Bingyang Dai, Shunxiang Xu, Wenxue Tong, Qing Lu, Patrick Shu-hang Yung, Michael Tim-yum Ong, Jiankun Xu, Ling Qin
會議名稱The HKOA 43rd Annual Congress of The Hong Kong Orthopaedic Association
會議開始日04.11.2023
會議完結日05.11.2023
會議地點Hong Kong
會議國家/地區香港
出版年份2023
月份11
出版社Hong Kong Academy of Medicine Press
出版地Hong Kong
頁次57 - 57
語言美式英語
